ArticleCanadian journal of psychiatry. Revue canadienne de psychiatrie2020
Brain-Wide Functional Dysconnectivity in Schizophrenia: Parsing Diathesis, Resilience, and the Effects of Clinical Expression.
Article in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration.Translational psychiatry · 2021Pooled it
- Impact of schizophrenia-associated risk genes on brain functional networks and executive deficits: a study of individuals with schizophrenia and genetic high risk.Psychological medicine · 2025Article
- Altered Brain-Behavior Association During Resting State is a Potential Psychosis Risk Marker.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Brain Markers of Resilience to Psychosis in High-Risk Individuals: A Systematic Review and Label-Based Meta-Analysis of Multimodal MRI Studies.Brain sciences · 2025Review
- Size and Topography of the Brain's Functional Networks with Psychotic Experiences, Schizophrenia, and Bipolar Disorder.Biological psychiatry global open science · 2024Article
- Functional brain network properties correlate with individual risk tolerance in young adults.Heliyon · 2024Article
- Exploring global and local processes underlying alterations in resting-state functional connectivity and dynamics in schizophrenia.Frontiers in psychiatry · 2024Article
- Psychological resilience mediates the protective role of default-mode network functional connectivity against COVID-19 vicarious traumatization.Translational psychiatry · 2023Article
- Controllability of Functional Brain Networks and Its Clinical Significance in First-Episode Schizophrenia.Schizophrenia bulletin · 2023Article
- Characterization of Hemodynamic Alterations in Schizophrenia and Bipolar Disorder and Their Effect on Resting-State fMRI Functional Connectivity.Schizophrenia bulletin · 2022Article
- Mediating Effect of Self-Efficacy on the Relationship Between Perceived Social Support and Resilience in Patients with Recurrent Schizophrenia in China.Neuropsychiatric disease and treatment · 2022Article
- Ultra-high field neuroimaging in psychosis: A narrative review.Frontiers in psychiatry · 2022Review
- Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?Antioxidants (Basel, Switzerland) · 2021Review
- The genetic determinants of language network dysconnectivity in drug-naïve early stage schizophrenia.NPJ schizophrenia · 2021Article
- Effective connectivity of the right anterior insula in schizophrenia: The salience network and task-negative to task-positive transition.NeuroImage. Clinical · 2020Article
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Authors and funding
6 authors.
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Abstract
backgroundThe functional dysconnectivity observed from functional magnetic resonance imaging (fMRI) studies in schizophrenia is also seen in unaffected siblings indicating its association with the genetic diathesis. We intended to apportion resting-state dysconnectivity into components that represent genetic diathesis, clinical expression or treatment effect, and resilience.
methodsfMRI data were acquired from 28 schizophrenia patients, 28 unaffected siblings, and 60 healthy controls. Based on Dosenbach's atlas, we extracted time series of 160 regions of interest. After constructing functional network, we investigated between-group differences in strength and diversity of functional connectivity and topological properties of undirected graphs.
resultsUsing analysis of variance, we found 88 dysconnectivities. Post hoc
conclusionA large portion of the resting-state functional dysconnectivity seen in patients represents a genetic diathesis effect. The most prominent network-level disruption is the dysconnectivity among nodes of the default mode and salience networks. Despite their predisposition, unaffected siblings show a pattern of resilience in the emergent connectomic topology. Our findings could potentially help refine imaging genetics approaches currently used in the pursuit of the pathophysiology of schizophrenia.
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