Evidence map›Paper›PMID 31775518›Full record

Trial reportCanadian journal of psychiatry. Revue canadienne de psychiatrie2020

Physical Activity as a Predictor of Clinical Trial Outcomes in Bipolar Depression: A Subanalysis of a Mitochondrial-Enhancing Nutraceutical Randomized Controlled Trial.

Melanie M Ashton, Mohammadreza Mohebbi, Alyna Turner, Wolfgang Marx, Michael Berk, Gin S Malhi, Chee H Ng, Sue M Cotton, Seetal Dodd, Jerome Sarris and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Nutraceuticals in Psychiatric Disorders: A Systematic Review.International journal of molecular sciences · 2024
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Aerobic exercise in severe mental illness: requirements from the perspective of sports medicine.European archives of psychiatry and clinical neuroscience · 2022
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Melanie M AshtonIMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Victoria, Australia.
Mohammadreza MohebbiBiostatistics Unit, Faculty of Health, Deakin University, Geelong, Victoria, Australia.
Alyna TurnerIMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Victoria, Australia.
Wolfgang MarxIMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Victoria, Australia.
Michael BerkIMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-5554-6946
Gin S MalhiAcademic Department of Psychiatry, Northern Sydney Local Health District, St Leonards, New South Wales, Australia.
Chee H NgProfessorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Richmond, Victoria, Australia.
Sue M CottonCentre of Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Seetal DoddIMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Victoria, Australia.
Jerome SarrisProfessorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Richmond, Victoria, Australia.
Malcolm HopwoodProfessorial Psychiatry Unit, Albert Road Clinic, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
Brendon StubbsPhysiotherapy Department, South London and Maudsley NHS Foundation Trust, London, United Kingdom.
Olivia M DeanIMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Victoria, Australia.

Funding

Department of Health ICA-CL-2017-03-001
6 · The paper itself

Abstract

objectivesIndividuals with bipolar disorder (BD) generally engage in low levels of physical activity (PA), and yet few studies have investigated the relationship between PA and change in BD symptom severity. The aim of this subanalysis of an adjunctive nutraceutical randomized controlled trial for the treatment of bipolar depression was to explore the relationship between PA, the active adjunctive treatments (a nutraceutical "mitochondrial cocktail"), and clinical outcomes.

methodsParticipants with bipolar depression were randomized to receive

resultsWeek-4 PA was not related to changes in Montgomery Åsberg Depression Rating Scale scores across the study until Week 20. However, participants who engaged in more PA and who received the combination treatment were more likely to have a reduction in scores on the Bipolar Depression Rating Scale (

conclusionsThis study provides novel evidence of the association between PA and reduction in BD symptoms in a nutraceutical clinical trial. However, further research assessing the potential synergistic effects of PA in BD is required.

Indexed as

Bipolar DisorderDietary SupplementsDouble-Blind MethodExerciseHumansQuality of LifeTreatment Outcomebipolar depressionbipolar disorderexercisemitochondrial agentsN-acetylcysteinenutraceuticalsphysical activity

Identifiers

PMID31775518
PMCPMC7265618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.