Evidence map›Paper›PMID 31775361›Full record

ArticleInternational journal of molecular sciences2019

The Precursor for Nerve Growth Factor (proNGF) in Thyroid Cancer Lymph Node Metastases: Correlation with Primary Tumour and Pathological Variables.

Christopher W Rowe, Tony Dill, Sam Faulkner, Craig Gedye, Jonathan W Paul, Jorge M Tolosa, Mark Jones, Simon King, Roger Smith, Hubert Hondermarck

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. ProNGF Expression and Targeting in Glioblastoma Multiforme.International journal of molecular sciences · 2023
    Article
  4. Role of NGF and its receptors in wound healing (Review).Experimental and therapeutic medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Christopher W RoweSchool of Medicine and Public Health, University of Newcastle, Callaghan, 2308, Australia.
Tony DillDepartment of Anatomical Pathology, NSW Health Pathology (Hunter), Newcastle, 2310, Australia.
Sam FaulknerHunter Medical Research Institute, 1 Kookaburra Circuit, New Lambton Heights, 2310, Australia.
Craig GedyeSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, 2308, Australia.
Jonathan W PaulSchool of Medicine and Public Health, University of Newcastle, Callaghan, 2308, Australia.
Jorge M TolosaSchool of Medicine and Public Health, University of Newcastle, Callaghan, 2308, Australia.
Mark JonesHunter Medical Research Institute, 1 Kookaburra Circuit, New Lambton Heights, 2310, Australia.
Simon KingHunter Medical Research Institute, 1 Kookaburra Circuit, New Lambton Heights, 2310, Australia.
Roger SmithSchool of Medicine and Public Health, University of Newcastle, Callaghan, 2308, Australia.
Hubert HondermarckHunter Medical Research Institute, 1 Kookaburra Circuit, New Lambton Heights, 2310, Australia.
Hunter Medical Research Institute · AUJohn Hunter Hospital · AUNew South Wales Department of Health · AUCalvary Mater Newcastle Hospital · AU

Funding

CSRD VA 1
6 · The paper itself

Abstract

Metastases in thyroid cancer are associated with aggressive disease and increased patient morbidity, but the factors driving metastatic progression are unclear. The precursor for nerve growth factor (proNGF) is increased in primary thyroid cancers, but its expression or significance in metastases is not known. In this study, we analysed the expression of proNGF in a retrospective cohort of thyroid cancer lymph node metastases (

Indexed as

Adenocarcinoma, FollicularAdultAgedBiomarkers, TumorCarcinoma, PapillaryFemaleHumansLymphatic MetastasisMaleMiddle AgedNerve Growth FactorPrognosisProspective StudiesProtein PrecursorsRetrospective StudiesThyroid NeoplasmsBiomarkers, TumorNerve Growth Factorpro-nerve growth factor, humanProtein PrecursorsmetastasisnervesneurotrophinproNGFThyroid cancer

Identifiers

PMID31775361
PMCPMC6929117
OpenAlexW2991262091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.