Evidence map›Paper›PMID 31775315›Full record

ArticleCells2019

MS CD49d

Paweł Piatek, Magdalena Namiecinska, Małgorzata Domowicz, Patrycja Przygodzka, Marek Wieczorek, Sylwia Michlewska, Natalia Lewkowicz, Maciej Tarkowski, Przemysław Lewkowicz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Remyelination in multiple sclerosis from the miRNA perspective.Frontiers in molecular neuroscience · 2023
    Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Paweł PiatekDepartment of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, Poland, Pomorska Str. 251, 92-213 Lodz, Poland.ORCID 0000-0003-1383-4672
Magdalena NamiecinskaDepartment of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, Poland, Pomorska Str. 251, 92-213 Lodz, Poland.
Małgorzata DomowiczDepartment of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, Poland, Pomorska Str. 251, 92-213 Lodz, Poland.ORCID 0000-0002-7804-9926
Patrycja PrzygodzkaInstitute of Medical Biology, Polish Academy of Sciences, 93-232 Lodz, Poland.ORCID 0000-0001-7529-8815
Marek WieczorekDepartment of Neurobiology, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.
Sylwia MichlewskaLaboratory of Microscopic Imaging and Specialized Biological Techniques, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.ORCID 0000-0002-8952-469X
Natalia LewkowiczDepartment of General Dentistry, Medical University of Lodz, 92-213 Lodz, Poland.
Maciej TarkowskiDepartment of Biomedical and Clinical Sciences, Luigi Sacco, University Hospital, University of Milan, 20122 Milano, Italy.ORCID 0000-0003-0061-9332
Przemysław LewkowiczDepartment of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, Poland, Pomorska Str. 251, 92-213 Lodz, Poland.ORCID 0000-0002-7098-9809
Medical University of Lodz · PLUniversity of Łódź · PLInstitute for Medical Biology · PLUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The critical aspect in multiple sclerosis (MS) progression involves insufficient regeneration of CNS resulting from deficient myelin synthesis by newly generated oligodendrocytes (OLs). Although many studies have focused on the role of autoreactive lymphocytes in the inflammatory-induced axonal loss, the problem of insufficient remyelination and disease progression is still unsolved. To determine the effect of myelin-specific lymphocytes on OL function in MS patients and in a mouse model of MS, we cultured myelin induced MS CD49d

Indexed as

LymphocytesMultiple SclerosisOligodendrogliaRemyelinationAdultAnimalsCell LineFemaleHumansMaleMiceMice, Inbred C57BLMicroRNAsMyelin Basic ProteinMyelin Proteolipid ProteinTranscriptional Elongation FactorsELL3 protein, humanMBP protein, humanMicroRNAsMIRN665 microRNA, humanMyelin Basic ProteinMyelin Proteolipid ProteinPLP1 protein, humanTranscriptional Elongation Factorsmultiple sclerosismyelin-specific lymphocytesoligodendrocyte precursor cellsremyelination

Identifiers

PMID31775315
PMCPMC6953114
OpenAlexW2990574486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.