ArticlePolymers2019
A Cu(II) Indicator Platform Based on Cu(II) Induced Swelling that Changes the Extent of Fluorescein Self-Quenching.
Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Synthesis of fluorescent Molecularly Imprinted Polymer Nanoparticles Sensing Small Neurotransmitters with High Selectivity Using Immobilized Templates with Regulated Surface Density.Nanomaterials (Basel, Switzerland) · 2023Article
- The Magical Combination of Polymer Science and Fluorometry.Polymers · 2020Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we established a new fluorescent indicator platform. The responsive element consists of poly(N-isopropylacrylamide) nanospheres that include small percentages of fluorescein and a ligand, anilinodiacetate (phenylIDA). Nanosphere diameters were determined to be in the range from 50 to 90 nm by scanning electron microscopy. They were entrapped in a polyacrylamide gel to prevent nanosphere aggregation. At pH 6, the ligand is negatively charged in the absence of metal ions. Charge-charge repulsion causes the nanosphere to swell. Dynamic light scattering measurements show that these nanospheres do not shrink and aggregate at high temperature. Cu(II) binding neutralizes the charge causing the particles to shrink. This brings fluoresceins closer together, increasing the degree of self-quenching. The intensity decreases by 30% as Cu(II) concentration increases. To rule out the possibility that the observed decrease in intensity was due to Cu(II) quenching of fluorescence, we also added Zn(II) and observed a decrease in intensity. This approach can be adapted to sense different metal ions and different concentrations of Cu(II) by changing the ligand.
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