Evidence map›Paper›PMID 31775224›Full record

ArticleInternational journal of molecular sciences2019

Simplified Head-to-Tail Cyclic Polypeptides as Biomaterial-Associated Antimicrobials with Endotoxin Neutralizing and Anti-Inflammatory Capabilities.

Na Dong, Chensi Wang, Xinran Li, Yuming Guo, Xiaoli Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Na DongThe Laboratory of Molecular Nutrition and Immunity, Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China.
Chensi WangThe Laboratory of Molecular Nutrition and Immunity, Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China.
Xinran LiThe Laboratory of Molecular Nutrition and Immunity, Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China.
Yuming GuoState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Xiaoli LiHeilongjiang Key Laboratory of Molecular Design and Preparation of Flame Retarded Materials, College of Science, Northeast Forestry University, Harbin 150040, China.

Funding

State Key Laboratory of Animal Nutrition 31402468the China Agriculture Research System CARS-35the Heilongjiang Province Natural Science Foundation LH2019C023the National Natural Science Foundation of China 31501914the National Natural Science Foundation of China 31972580
6 · The paper itself

Abstract

The therapeutic application of antimicrobial peptides (AMPs), a potential type of peptide-based biomaterial, is impeded by their poor antimicrobial activity and potential cytotoxicity as a lack of understanding of their structure-activity relationships. In order to comprehensively enhance the antibacterial and clinical application potency of AMPs, a rational approach was applied to design amphiphilic peptides, including head-to-tail cyclic, linear and D-proline antimicrobial peptides using the template (IR)

Indexed as

Adjuvants, ImmunologicAnimalsAnti-Bacterial AgentsAnti-Inflammatory AgentsAntimicrobial Cationic PeptidesBiocompatible MaterialsCell DeathDermatitisEndotoxinsHemolysisHumansLipopolysaccharidesMaleMiceMice, Inbred ICROxazoloneAdjuvants, ImmunologicAnti-Bacterial AgentsAnti-Inflammatory AgentsAntimicrobial Cationic PeptidesBiocompatible MaterialsEndotoxinsLipopolysaccharidesOxazolonePeptidesPeptides, Cyclicbactericidal mechanismcell selectivityhead-to-tail cyclic antimicrobial peptidesmembraneskin inflammation

Identifiers

PMID31775224
PMCPMC6928678

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.