ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020
Prior cocaine self-administration impairs attention signals in anterior cingulate cortex.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Cocaine Hijacks the Npas4-dependent Somatostatin Ensembles in the mPFC to Mediate Attention.Neuroscience bulletin · 2026Article
- The psychedelic (-)-2,5-dimethoxy-4-iodoamphetamine [(-)-DOI] demonstrates efficacy in reducing cocaine reward and motivation in male rats.Psychopharmacology · 2025Article
- Anterior cingulate cortex lesions impair multiple facets of task engagement not mediated by dorsomedial striatum neuron firing.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Optogenetic Inhibition of Rat Anterior Cingulate Cortex Impairs the Ability to Initiate and Stay on Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Attentional function and inhibitory control in different substance use disorders.Psychiatry research · 2022Article
- Insula lesions reduce stimulus-driven control of behavior during odor-guided decision-making and autoshaping.Brain research · 2022Article
- Percentage amplitude of fluctuation and structural covariance changes of subjective cognitive decline in patients: A multimodal imaging study.Frontiers in neuroscience · 2022Article
- Neural signals implicated in the processing of appetitive and aversive events in social and non-social contexts.Frontiers in systems neuroscience · 2022Review
- Overexpressing Histone Deacetylase 5 in Rat Dorsal Striatum Alters Reward-Guided Decision-Making and Associated Neural Encoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Prior Cocaine Exposure Increases Firing to Immediate Reward While Attenuating Cue and Context Signals Related to Reward Value in the Insula.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Anhydroecgonine methyl ester, a cocaine pyrolysis product, contributes to cocaine-induced rat primary hippocampal neuronal death in a synergistic and time-dependent manner.Archives of toxicology · 2021Article
- Prediction errors and valence: From single units to multidimensional encoding in the amygdala.Behavioural brain research · 2021Review
- Anterior Cingulate Cortex Signals Attention in a Social Paradigm that Manipulates Reward and Shock.Current biology : CB · 2020Article
- In vivo reduction of striatal D1R by RNA interference alters expression of D1R signaling-related proteins and enhances methamphetamine addiction in male rats.Brain structure & function · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Although maladaptive decision-making is a defining feature of drug abuse and addiction, we have yet to ascertain how cocaine self-administration disrupts neural signals in anterior cingulate cortex (ACC), a brain region thought to contribute to attentional control. To address this issue, rats were trained on a reward-guided decision-making task; reward value was manipulated by independently varying the size of or the delay to reward over several trial blocks. Subsequently, rats self-administered either a cocaine (experimental group) or sucrose (control) during 12 consecutive days, after which they underwent a 1-month withdrawal period. Upon completion of this period, rats performed the previously learned reward-guided decision-making task while we recorded from single neurons in ACC. We demonstrate that prior cocaine self-administration attenuates attention and attention-related ACC signals in an intake-dependent manner, and that changes in attention are decoupled from ACC firing. These effects likely contribute to the impaired decision-making-typified by chronic substance abuse and relapse-observed after drug use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.