Evidence map›Paper›PMID 31775157›Full record

ArticleNature2020

FACT caught in the act of manipulating the nucleosome.

Yang Liu, Keda Zhou, Naifu Zhang, Hui Wei, Yong Zi Tan, Zhening Zhang, Bridget Carragher, Clinton S Potter, Sheena D'Arcy, Karolin Luger

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 231 citations in OpenAlex.

  1. Article
  2. A recurrentBiochemistry and biophysics reports · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Histone Variant H2A.Z Enhances Histone and Nucleosome Dynamics.Molecular & cellular proteomics : MCP · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Yang Liu *Department of Biochemistry, University of Colorado at Boulder, Boulder, CO, USA.
Keda Zhou *Department of Biochemistry, University of Colorado at Boulder, Boulder, CO, USA.
Naifu ZhangDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Dallas, TX, USA.
Hui WeiNational Resource for Automated Molecular Microscopy Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.
Yong Zi TanNational Resource for Automated Molecular Microscopy Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.
Zhening ZhangNational Resource for Automated Molecular Microscopy Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.
Bridget CarragherNational Resource for Automated Molecular Microscopy Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.
Clinton S PotterNational Resource for Automated Molecular Microscopy Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.
Sheena D'ArcyDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Dallas, TX, USA.
Karolin LugerDepartment of Biochemistry, University of Colorado at Boulder, Boulder, CO, USA. karolin.luger@colorado.edu.
New York Structural Biology Center · USThe University of Texas at Dallas · USUniversity of Colorado Boulder · USColumbia University Irving Medical Center · USHoward Hughes Medical Institute · US

Funding

ZWITTERION SURFACTANT DDMAB FOR IMPROV STABIL OF PROTEINP41RR001209 · NCRR · STANFORD UNIVERSITY · PI GONZALEZ, ANA M · 1985 to 2011
$38.9M
TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7M
The Role of Dynamics in Regulating Multi-Activity Protein Complexes and ChromatinR35GM133751 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Sheena D'Arcy · 2019 to 2026
$2.9M
Acquisition of Detector for JEOL 3200 FSC Electron MicroscopeS10OD019994 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI CARRAGHER, BRIDGET OLIVIA · 2015 to 2015
$600k
Howard Hughes Medical InstituteNCRR NIH HHS P41 RR001209NIGMS NIH HHS GM133751NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R35 GM133751NIH HHS S10 OD019994
6 · The paper itself

Abstract

The organization of genomic DNA into nucleosomes profoundly affects all DNA-related processes in eukaryotes. The histone chaperone known as 'facilitates chromatin transcription' (FACT

Indexed as

Cell Cycle ProteinsCryoelectron MicroscopyDNADNA-Binding ProteinsHigh Mobility Group ProteinsHistonesHumansModels, MolecularNucleosomesProtein Structure, QuaternaryProtein Structure, TertiaryTranscriptional Elongation FactorsTranscription FactorsCell Cycle ProteinsDNADNA-Binding ProteinsHigh Mobility Group ProteinsHistonesNucleosomesSSRP1 protein, humanSUPT16H protein, humanTranscriptional Elongation FactorsTranscription Factors

Identifiers

PMID31775157
PMCPMC7441595
OpenAlexW2990803388

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.