ArticleCell reports2019
Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Thymic APC Networks Orchestrate T-Cell Selection: Mechanisms and Therapeutic Opportunities in Immune Disorders.Immunology · 2026Review
- Proteasome alteration between epithelial and hematopoietic cells facilitates positive selection of CD8 T cells.Nature communications · 2026Article
- SKI Regulates Medullary Thymic Epithelial Cell Differentiation to Control Peripheral T Cell Responses in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Article
- Article
- Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells.Science immunology · 2023Article
- The thymoproteasome in shaping the CD8Current opinion in immunology · 2023Review
- Large-Scale Isolation of Mouse Thymic Epithelial Cells.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Tissue-specific proteasomes in generation of MHC class I peptides and CD8Current opinion in immunology · 2022Review
- Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development.eLife · 2022Article
- Key Factors for Thymic Function and Development.Frontiers in immunology · 2022Review
- Peptides for T cell selection in the thymus.Peptides · 2021Review
- Specific impact of β5t on proteasome subunit composition in cortical thymic epithelial cells.Cell reports · 2021Article
- The thymoproteasome hardwires the TCR repertoire of CD8+ T cells in the cortex independent of negative selection.The Journal of experimental medicine · 2021Article
- Thymus Degeneration and Regeneration.Frontiers in immunology · 2021Review
- Thymoproteasome optimizes positive selection of CD8Advances in immunology · 2021Review
- The Role of Proteasomes in the Thymus.Frontiers in immunology · 2021Review
- PITHD1 is a proteasome-interacting protein essential for male fertilization.The Journal of biological chemistry · 2020Article
- Thymoproteasome-Expressing Mesenchymal Stromal Cells Confer Protective Anti-Tumor ImmunityFrontiers in immunology · 2020Article
- Postnatal Involution and Counter-Involution of the Thymus.Frontiers in immunology · 2020Review
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Authors and funding
18 authors at 6 institutions in 2 countries.
Funding
Abstract
The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs). Recent studies including single-cell transcriptomic analyses have highlighted a rich diversity in functional mTEC subpopulations. Because of their limited cellularity, however, the biochemical characterization of TECs, including the proteomic profiling of cTECs and mTECs, has remained unestablished. Utilizing genetically modified mice that carry enlarged but functional thymuses, here we show a combination of proteomic and transcriptomic profiles for cTECs and mTECs, which identified signature molecules that characterize a developmental and functional contrast between cTECs and mTECs. Our results reveal a highly specific impact of the thymoproteasome on proteasome subunit composition in cTECs and provide an integrated trans-omics platform for further exploration of thymus biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.