Evidence map›Paper›PMID 31775045›Full record

ArticleCell reports2019

Latency-Reversing Agents Induce Differential Responses in Distinct Memory CD4 T Cell Subsets in Individuals on Antiretroviral Therapy.

Marion Pardons, Rémi Fromentin, Amélie Pagliuzza, Jean-Pierre Routy, Nicolas Chomont

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
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  7. HIV-1 latency reversal agent boosting is not limited by opioid use.medRxiv : the preprint server for health sciences · 2024
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  17. The role of latency reversal in HIV cure strategies.Journal of medical primatology · 2022
    Review
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Marion PardonsCentre de Recherche du CHUM, Montreal, QC, Canada; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada.
Rémi FromentinCentre de Recherche du CHUM, Montreal, QC, Canada.
Amélie PagliuzzaCentre de Recherche du CHUM, Montreal, QC, Canada.
Jean-Pierre RoutyDivision of Hematology and Chronic Viral Illness Service, McGill University, Montreal, QC, Canada.
Nicolas ChomontCentre de Recherche du CHUM, Montreal, QC, Canada; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada. Electronic address: nicolas.chomont@umontreal.ca.
Centre Hospitalier de l’Université de Montréal · CAMcGill University · CA

Funding

Delaney AIDS Research Enterprise to Cure HIVUM1AI126611 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, PICKER, LOUIS J. · 2016 to 2020
$27.9M
Mechanisms of HIV persistence in distinct memory CD4+ T cell subsets in blood andR56AI108435 · NIAID · VGTI FLORIDA · PI CHOMONT, NICOLAS · 2014 to 2014
$473k
Canadian Institutes for Health Research (CIHR)NIAID NIH HHS R56 AI108435NIAID NIH HHS UM1 AI126611
6 · The paper itself

Abstract

Latent proviruses persist in central (T

Indexed as

Anti-Retroviral AgentsCD4-Positive T-LymphocytesHIV InfectionsHumansAnti-Retroviral AgentsCD4 T cellshistone acetylationHIV-FlowHIV reservoirlatencylatency-reversing agentLRAmemory subsetsNF-κBP-TEFb

Identifiers

PMID31775045
PMCPMC6943937
OpenAlexW2990871121

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.