Evidence map›Paper›PMID 31775030›Full record

ArticleCell reports2019

Network-Targeted, Multi-site Direct Cortical Stimulation Enhances Working Memory by Modulating Phase Lag of Low-Frequency Oscillations.

Sankaraleengam Alagapan, Justin Riddle, Wei Angel Huang, Eldad Hadar, Hae Won Shin, Flavio Fröhlich

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06252532 (Modulating Oscillations and Working Memory in Patients With Subdural Electrodes), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06252532 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Modulating Oscillations and Working Memory in Patients With Subdural Electrodes

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2024 to 2027Enrolled50ConditionsWorking Memory, EpilepsyArmsDirect cortical stimulation (DCS) Alpha, Direct cortical stimulation (DCS) Theta, Sham Direct cortical stimulation (DCS), Direct cortical stimulation (DCS) In-Phase Theta, Direct cortical stimulation (DCS) Anti-Phase Theta
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

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  13. Emergence of Neuronal Synchronisation in Coupled Areas.Frontiers in computational neuroscience · 2021
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sankaraleengam AlagapanCarolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Justin RiddleCarolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Wei Angel HuangDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Eldad HadarDepartment of Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Hae Won ShinDepartment of Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Flavio FröhlichCarolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: flavio_frohlich@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Targeting Cortical Dynamics: Rational Design of Individualized Brain StimulationR01MH101547 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FROHLICH, FLAVIO · 2013 to 2017
$2.2M
Modulating Oscillations and Working Memory in Patients with Subdural ElectrodesR21NS094988 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FROHLICH, FLAVIO, SHIN, HAE WON · 2017 to 2018
$418k
Multistable Dynamics of Connected Cortical Networks: Mechanisms and ModulationR21MH105557 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FROHLICH, FLAVIO · 2014 to 2015
$401k
NIMH NIH HHS R01 MH101547NIMH NIH HHS R21 MH105557NINDS NIH HHS R21 NS094988
6 · The paper itself

Abstract

Working memory is mediated by the coordinated activation of frontal and parietal cortices occurring in the theta and alpha frequency ranges. Here, we test whether electrically stimulating frontal and parietal regions at the frequency of interaction is effective in modulating working memory. We identify working memory nodes that are functionally connected in theta and alpha frequency bands and intracranially stimulate both nodes simultaneously in participants performing working memory tasks. We find that in-phase stimulation results in improvements in performance compared to sham stimulation. In addition, in-phase stimulation results in decreased phase lag between regions within working memory network, while anti-phase stimulation results in increased phase lag, suggesting that shorter phase lag in oscillatory connectivity may lead to better performance. The results support the idea that phase lag may play a key role in information transmission across brain regions. Thus, brain stimulation strategies to improve cognition may require targeting multiple nodes of brain networks.

Indexed as

Brain MappingElectroencephalographyFemaleHumansMaleMemory, Short-Termbrain stimulationcortical oscillationsdirect cortical stimulationhuman neuroscienceintracranial eegphase lagworking memory

Identifiers

PMID31775030
PMCPMC6901101
OpenAlexW2989969517

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.