ArticlePloS one2019
Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Pooled it
- Platelet Reactivity and Sex Differences: Clinical Implications for Women.Circulation research · 2026Review
- Morphological and clinical predictors of symptomatic carotid webs: a cross-validated analysis of 124 webs.Neuroradiology · 2026Article
- Sex differences in circulating platelet-derived CD41+ extracellular vesicles in healthy adults.Physiological reports · 2026Article
- Beyond Linear Risk: A U-Shaped Association Between Platelet Reactivity and Mortality in Coronary Artery Disease.Diseases (Basel, Switzerland) · 2026Article
- Article
- Risk Factors for Preoperative DVT in Elderly Patients with Hip Fractures.Journal of clinical medicine · 2026Article
- Sex and gender differences in hemostasis in critical illness.Critical care science · 2026Review
- Association between patient signalment and platelet function parameters in cats.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Influence of age and sex on platelet count: Implications for optimizing growth factor-rich plasma preparation.Journal of clinical and experimental dentistry · 2025Review
- Comparative Effectiveness of Clopidogrel Versus Aspirin for Primary Prevention in High-Risk Patients with Type 2 Diabetes: A Nationwide Propensity Score-Matched Cohort Study.Medicina (Kaunas, Lithuania) · 2025Article
- Sex-related variations in platelet reactivity in presence or absence of antiplatelet therapy.European heart journal. Cardiovascular pharmacotherapy · 2025Article
- Non-invasive fibrosis tools lack clinical utility for identifying advanced fibrosis in Fontan-associated liver disease: a retrospective cohort study.BMJ open gastroenterology · 2025Article
- Impact of aspirin therapy on progression of thoracic and abdominal aortic aneurysms.Atherosclerosis · 2025Article
- A map of blood regulatory variation in South Africans enables GWAS interpretation.Nature genetics · 2025Article
- The relationship between ABO blood types and clopidogrel-related low on-treatment platelet reactivity in patients with coronary artery diseases and type 2 diabetes mellitus: a secondary analysis of a prospective cohort study.Diabetology & metabolic syndrome · 2025Article
- Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities.ESC heart failure · 2025Review
- Association between serum Klotho levels and thrombocytosis in aging adults based on evidence from the National Health and Nutrition Examination Survey.Scientific reports · 2025Article
- Evaluation of sex-based differences in below-the-knee plaque histology in patients who underwent amputation for chronic limb-threatening ischemia.JVS-vascular science · 2025Article
- Association between serum 25-hydroxyvitamin D concentrations and platelet to high-density lipoprotein cholesterol ratio: evidence from two population-based studies.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGender influences platelet biology. Women have a larger platelet count, but gender-based differences in platelet function remain debated. We performed a study addressing gender-based differences in platelet function using point-of-care platelet function tests (PFT).
methodsThe patient population consisted of 760 cardiac surgery patients where preoperative PFT (multiple-electrode aggregometry [MEA]) were available. Platelet count and function at the ADPtest and TRAPtest were compared in the overall population and separately in patients with or without residual effects of P2Y12 inhibitors.
resultsWomen had a significantly (P = 0.001) higher platelet count but a non-significantly higher platelet reactivity to ADP. In clopidogrel-treated patients, the platelets ADP reactivity was significantly (P = 0.031) higher in women, and platelet count was the main determinant of platelet hyper-reactivity. Within patients under full clopidogrel effects, women with a platelet count ≥ 200,000 cells/μL had a significantly (P = 0.023) higher rate of high-on-treatment platelet reactivity (HTPR, 45.5%) with respect to males with a platelet count < 200,000 cells/μL (11.9%), with a relative risk of 6.2 (95% confidence interval 1.4-29).
conclusionsOur findings confirm that women have a larger platelet count than men, and that this is associated to a trend towards a higher platelet reactivity. HTPR is largely represented in women with a high platelet count. This generates the hypothesis that women requiring P2Y12 inhibitors could potentially benefit from larger doses of drug or should be treated with anti-platelet agents with a low rate of HTPR.
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Registered trials
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