ArticleMedical science monitor : international medical journal of experimental and clinical research2019
Plasma D-Dimer Level Is an Early Predictor of Severity of Acute Pancreatitis Based on 2012 Atlanta Classification.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Global burden and characterization of hypertriglyceridemia-induced acute pancreatitis: results from a systematic review and a multi-center cohort study.Science China. Life sciences · 2025Pooled it
- Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Prognostic value of admission D-dimer in acute pancreatitis: association with disease severity and clinical outcomes in a retrospective cohort study.BMC gastroenterology · 2026Article
- Inpatient Outcomes of Atrial Fibrillation in Patients With Acute Pancreatitis: Insights From the TriNetX Database.Journal of arrhythmia · 2026Article
- Prompt cesarean delivery in late pregnancy for hyperlipidemia-induced pancreatitis: a case report.Clinical journal of gastroenterology · 2026Article
- The role of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in predicting the severity of acute biliary pancreatitis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- The value of NLR, PLR, PCT, and D-D levels in assessing the severity of hyperlipidemic acute pancreatitis.Frontiers in medicine · 2025Article
- Serial D-dimer measurements dynamically predict disease severity in acute biliary pancreatitis: a prospective observational study.Turkish journal of medical sciences · 2025Observational
- Article
- Nomogram and Web Calculator Based on Lasso-Logistic Regression for Predicting Persistent Organ Failure in Acute Pancreatitis Patients.Journal of inflammation research · 2024Article
- Predictive role of lactate in dogs with acute pancreatitis advanced to systemic inflammatory response syndrome.Veterinary research forum : an international quarterly journal · 2024Article
- Development and Validation of a Nomogram for Predicting the Severity of the First Episode of Hyperlipidemic Acute Pancreatitis.Journal of inflammation research · 2024Article
- The value of immature granulocyte percentage united with D-Dimer in the evaluation of severe pancreatitis and its prognosis.Clinics (Sao Paulo, Brazil) · 2024Article
- Fibrinogen-like Protein 1 as a Predictive Marker for the Incidence of Severe Acute Pancreatitis and Infectious Pancreatic Necrosis.Medicina (Kaunas, Lithuania) · 2022Article
- Triglyceride to HDL-C ratio is associated with plasma D-dimer levels in different types of pancreatitis.Scientific reports · 2022Article
- [Association between coagulation function and prognosis in patients with acute pancreatitis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Diagnostic utility of hematological indices in predicting adverse outcomes and severity of acute pancreatitis based on BISAP and modified Glasgow score.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Increased thromboembolic risk in non-neoplastic pancreatic diseases: A review focusing on acute pancreatitis.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Acute pancreatitis (AP) is a common digestive disorder. Its management depends on the severity; therefore, it is essential to stratify AP patients early. D-dimer, a coagulation indicator, appears to be associated with the pathogenesis of AP. The aim of this study was to evaluate D-dimer as an early predictor of the severity of AP. MATERIAL AND METHODS This was a single-center retrospective study of 1260 patients diagnosed based on the revised Atlanta classification. Only patients hospitalized within 24 h of onset were included, and 334 patients were enrolled. Blood was collected at admission and 3 times within 48 h of admission. Values at admission and average of the 3 blood samples were evaluated by univariate and multivariate analyses. Furthermore, the area under the receiver-operating characteristic curve (AUC) was used to estimate the validity of the predictor and to define optimal cut-off points for prediction. RESULTS We found that 53.3% of the patients had mild AP (MAP), 24.3% had moderately severe AP (MSAP), and 22.4% had severe AP (SAP). D-dimer at admission and the average D-dimer could distinguish MAP patients from MSAP and SAP patients, with cut-off values of 3.355 mg/L and 4.868 mg/L, respectively. No difference in the parameters at admission was observed in multivariate analysis in distinguishing SAP from MSAP, but the average D-dimer level was significantly different with a cut-off value of 7.268 mg/L by comparing Ranson score, APACHE II score, and D-dimer level. CONCLUSIONS The average value of D-dimer levels could be used as a predictor of severity of AP. In general, patients with an average D-dimer level <4.868 could be diagnosed with MAP, >7.268 would develop into SAP, and between 4.868 and 7.268 would be MSAP.
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