Evidence map›Paper›PMID 31774725›Full record

ArticleMolecular biology of the cell2020

Basic-hydrophobic sites are localized in conserved positions inside and outside of PH domains and affect localization of

Hanna Brzeska, Jesus Gonzalez, Edward D Korn, Margaret A Titus

Open access · bronzeAbstract read
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hanna BrzeskaLaboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Jesus GonzalezLaboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Edward D KornLaboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Margaret A TitusDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455.
National Heart Lung and Blood Institute · USUniversity of Minnesota · US

Funding

Mechanism of myosin motor-dependent filopodia formationR01GM122917 · NIGMS · UNIVERSITY OF MINNESOTA · PI TITUS, MARGARET A · 2017 to 2024
$3.2M
NIGMS NIH HHS R01 GM122917
6 · The paper itself

Abstract

Myosin 1s have critical roles in linking membranes to the actin cytoskeleton via direct binding to acidic lipids. Lipid binding may occur through PIP3/PIP2-specific PH domains or nonspecific ionic interactions involving basic-hydrophobic (BH) sites but the mechanism of myosin 1s distinctive lipid targeting is poorly understood.  Now we show that PH domains occur in all

Indexed as

Actin CytoskeletonActinsBinding SitesCell MembraneDictyosteliumHydrophobic and Hydrophilic InteractionsMyosinsMyosin Type IPleckstrin Homology DomainsProtein DomainsProtein TransportProtozoan ProteinsActinsMyosinsMyosin Type IProtozoan Proteins

Identifiers

PMID31774725
PMCPMC6960411
OpenAlexW2991623995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.