Evidence map›Paper›PMID 31774690›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2020

Spinal cord injury alters purinergic neurotransmission to mesenteric arteries in rats.

Sutheera Sangsiri, Hui Xu, Roxanne Fernandes, Greg D Fink, Heidi L Lujan, Stephen E DiCarlo, James J Galligan

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Sutheera SangsiriDepartment of Preclinical Science, Thammasat University, Pathumthani, Thailand.
Hui XuDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan.
Roxanne FernandesDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan.
Greg D FinkDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan.
Heidi L LujanDepartment of Physiology, Michigan State University, East Lansing, Michigan.
Stephen E DiCarloDepartment of Physiology, Michigan State University, East Lansing, Michigan.
James J GalliganDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan.
Michigan State University · USThammasat University · TH

Funding

SIGNALING MECHANISMS IN ARTERIES AND VEINS IN HYPERTENSIONP01HL070687 · NHLBI · MICHIGAN STATE UNIVERSITY · PI FINK, GREGORY D · 2003 to 2019
$22.8M
Vagal Plasticity after Cord Injury Exacerbates Post-Infarct Cardiac RemodelingR01HL122223 · NHLBI · WAYNE STATE UNIVERSITY · PI DICARLO, STEPHEN E · 2015 to 2018
$1.5M
NHLBI NIH HHS P01 HL070687NHLBI NIH HHS R01 HL122223
6 · The paper itself

Abstract

Complications associated with spinal cord injury (SCI) result from unregulated reflexes below the lesion level. Understanding neurotransmission distal to the SCI could improve quality of life by mitigating complications. The long-term impact of SCI on neurovascular transmission is poorly understood, but reduced sympathetic activity below the site of SCI enhances arterial neurotransmission (1). We studied sympathetic neurovascular transmission using a rat model of long-term paraplegia (T2-3) and tetraplegia (C6-7). Sixteen weeks after SCI, T2-3 and C6-7 rats had lower blood pressure (BP) than sham rats (103  ±  2 and 97  ±  4 vs. 117  ±  6 mmHg,

Indexed as

Synaptic TransmissionAdenosine TriphosphateAnimalsBlood PressureBradycardiaExcitatory Postsynaptic PotentialsMaleMesenteric ArteriesNorepinephrineParaplegiaQuadriplegiaRatsRats, Sprague-DawleyReceptors, PurinergicSpinal Cord InjuriesSympathetic Nervous SystemAdenosine TriphosphateNorepinephrineReceptors, Purinergicexcitatory junction potentialmesenteric arteriespurinergic neurotransmissionspinal cord injurysympathetic neurotransmission

Identifiers

PMID31774690
PMCPMC7052627
OpenAlexW2991085287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.