Evidence map›Paper›PMID 31774353›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2020

Aging reduces succinate dehydrogenase activity in rat type IIx/IIb diaphragm muscle fibers.

Matthew J Fogarty, Natalia Marin Mathieu, Carlos B Mantilla, Gary C Sieck

Open access · bronzeAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Age-related changes in respiratory system mechanics and lung morphometry.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  8. Article
  9. TNFα-mediated subcellular heterogeneity of succinate dehydrogenase activity in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Sarcopenia of the longitudinal tongue muscles in rats.Respiratory physiology & neurobiology · 2024
    Article
  15. Mitochondrial heterogeneity in diseases.Signal transduction and targeted therapy · 2023
    Review
  16. Article
  17. Article
  18. Size-dependent differences in mitochondrial volume density in phrenic motor neurons.Journal of applied physiology (Bethesda, Md. : 1985) · 2023
    Article
  19. Article
  20. Satellite cell depletion does not affect diaphragm adaptations to hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Matthew J FogartyDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Natalia Marin MathieuDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Carlos B MantillaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Gary C SieckDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Mayo Clinic · US

Funding

Respiratory Control in Old AgeR01AG044615 · NIA · MAYO CLINIC ROCHESTER · PI MANTILLA, CARLOS B, SIECK, GARY C. · 2013 to 2025
$6.9M
Enhancing Respiratory Motor Function after Spinal Cord InjuryR01HL146114 · NHLBI · MAYO CLINIC ROCHESTER · PI Carlos B Mantilla, Gary C. Sieck · 2019 to 2026
$5.4M
Mechanisms of age-related susceptibility of NMJ functionR01AG057052 · NIA · MAYO CLINIC ROCHESTER · PI MANTILLA, CARLOS B, SIECK, GARY C. · 2017 to 2021
$2.0M
NHLBI NIH HHS R01 HL146114NIA NIH HHS R01 AG044615NIA NIH HHS R01 AG057052
6 · The paper itself

Abstract

In aged rats, diaphragm muscle (DIAm) reduced specific force and fiber cross-sectional area, sarcopenia, is selective for vulnerable type IIx and/or IIb DIAm fibers, with type I and IIa fibers being resilient. In humans, the oxidative capacity [as measured by maximum succinate dehydrogenase (SDH

Indexed as

AgingAnimalsDiaphragmFemaleMaleMuscle Fibers, SkeletalRatsRats, Inbred F344SarcopeniaSuccinate DehydrogenaseSuccinate Dehydrogenaseagingdiaphragmfiber typeoxygen consumptionsarcopeniasuccinate dehydrogenase

Identifiers

PMID31774353
PMCPMC6985814
OpenAlexW2990020081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.