Evidence map›Paper›PMID 31774280›Full record

ArticleInorganic chemistry2019

Enhancement of the Antioxidant Activity and Neurotherapeutic Features through Pyridol Addition to Tetraazamacrocyclic Molecules.

Hannah M Johnston, Kristof Pota, Madalyn M Barnett, Olivia Kinsinger, Paige Braden, Timothy M Schwartz, Emily Hoffer, Nishanth Sadagopan, Nam Nguyen, Yu Yu and 6 more

Abstract read
In one paragraph

Article in Inorganic chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  5. Predicting pRSC advances · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hannah M Johnston
Kristof Pota
Madalyn M Barnett
Olivia Kinsinger
Paige Braden
Timothy M Schwartz
Emily Hoffer
Nishanth Sadagopan
Nam Nguyen
Yu Yu
Paulina Gonzalez
Gyula TircsóDepartment of Inorganic and Analytical Chemistry, Faculty of Science and Technology , University of Debrecen , Egyetem tér 1 , Debrecen H-4010 , Hungary.ORCID http://orcid.org/0000-0002-7896-7890
Hongli Wu
Giridhar Akkaraju
Michael J Chumley

Funding

Targeting oxidative stress in neurodegeneration using pyridol-derived small moleculesR15GM123463 · NIGMS · TEXAS CHRISTIAN UNIVERSITY · PI AKKARAJU, GIRIDHAR, CHUMLEY, MICHAEL J · 2018 to 2025
$1.2M
NIGMS NIH HHS R15 GM123463
6 · The paper itself

Abstract

Alzheimer's and other neurodegenerative diseases are chronic conditions affecting millions of individuals worldwide. Oxidative stress is a consistent component described in the development of many neurodegenerative diseases. Therefore, innovative strategies to develop drug candidates that overcome oxidative stress in the brain are needed. To target these challenges, a new, water-soluble 12-membered tetraaza macrocyclic pyridinophane

Identifiers

PMID31774280
PMCPMC7323501

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.