Evidence map›Paper›PMID 31774122›Full record

ArticleThe Journal of clinical endocrinology and metabolism2020

Parathyroid Hormone and Plasma Phosphate Are Predictors of Soluble α-Klotho Levels in Adults of European Descent.

Nasser A Dhayat, Menno Pruijm, Belen Ponte, Daniel Ackermann, Alexander Benedikt Leichtle, Olivier Devuyst, Georg Ehret, Idris Guessous, Antoinette Pechère-Bertschi, Johanne Pastor and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Nasser A DhayatDepartment of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Menno PruijmNephrology Service, Lausanne University Hospital, Lausanne, Switzerland.
Belen PonteNephrology Service, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva, Switzerland.
Daniel AckermannDepartment of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Alexander Benedikt LeichtleDepartment of Laboratory Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Olivier DevuystInstitute of Physiology, University of Zurich, Zurich, Switzerland.
Georg EhretCardiology Service, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva, Switzerland.
Idris GuessousDivision of Primary Care Medicine, Geneva University Hospital, Geneva, Switzerland.
Antoinette Pechère-BertschiEndocrinology Service, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva, Switzerland.
Johanne PastorCharles and Jane Pak Center of Mineral Metabolism and Clinical Research, Department of Physiology and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Pierre-Yves MartinNephrology Service, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva, Switzerland.
Michel BurnierNephrology Service, Lausanne University Hospital, Lausanne, Switzerland.
Georg-Martin FiedlerDepartment of Laboratory Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Bruno VogtDepartment of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Orson W MoeCharles and Jane Pak Center of Mineral Metabolism and Clinical Research, Department of Physiology and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Murielle BochudCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Daniel G FusterDepartment of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
University of Bern · CHUniversity Hospital of Geneva · CHThe University of Texas Southwestern Medical Center · USUniversity of Lausanne · CHCentre universitaire de médecine générale et santé publique, Lausanne · CHUniversity of Zurich · CH

Funding

UT Southwestern O'Brien Kidney Research Core CenterP30DK079328 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MOE, ORSON W · 2007 to 2021
$16.9M
Pathogenesis of Uric Acid Nephrolithiasis: The Multifaceted Role of Renal LipidsR01DK081423 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MAALOUF, NAIM M, MOE, ORSON W · 2009 to 2023
$6.1M
Klotho: Therapeutic Agent for Ischemia Reperfusion Induced Acute Kidney InjuryR01DK092461 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HU, MING-CHANG · 2011 to 2021
$3.7M
Klotho and Phosphate in Chronic Kidney Disease: Pathogenesis and TherapeuticsR01DK091392 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HU, MING-CHANG, MOE, ORSON W · 2011 to 2021
$3.2M
NIDDK NIH HHS P30 DK079328NIDDK NIH HHS R01 DK081423NIDDK NIH HHS R01 DK091392NIDDK NIH HHS R01 DK092461
6 · The paper itself

Abstract

contextα-klotho is an integral membrane protein that serves as a coreceptor for fibroblast growth factor 23 (FGF23) in conjunction with cognate fibroblast growth factor receptors. Proteolytic cleavage sheds the ectodomain of α-klotho (soluble α-klotho) as an endocrine substance into blood, urine, and cerebrospinal fluid.

objectiveTo study the relationship of soluble α-klotho to mineral metabolism in the general population with mainly preserved kidney function.

designCross-sectional analysis of the associations between soluble α-klotho with laboratory markers of markers of mineral metabolism in a population-based cohort.

settingThree centers in Switzerland including 1128 participants. MEASURES: Soluble full-length α-klotho levels by a specific immunoassay and markers of mineral metabolism.

resultsThe median serum level of soluble α-klotho was 15.0 pmol/L. Multivariable analyses using α-klotho as the outcome variable revealed a sex-by-PTH interaction: In men, PTH was positively associated with α-klotho levels, whereas this association was negative in women. Plasma phosphate associated with soluble α-klotho levels in an age-dependent manner, changing from a positive association in young adults gradually to a negative association in the elderly. The decline of 1,25 (OH)2 vitamin D3 levels in parallel to the gradual impairment of kidney function was greatly attenuated in the setting of high circulating soluble α-klotho levels.

conclusionsSoluble α-klotho level is associated with plasma phosphate in an age-dependent manner and with PTH in a sex-dependent manner. Furthermore, our data reveal soluble α-klotho as a modulator of 1,25 (OH)2 vitamin D3 levels in individuals with preserved renal function.

Indexed as

AdolescentAdultAgedAged, 80 and overBiomarkersCross-Sectional StudiesFemaleFibroblast Growth Factor-23Follow-Up StudiesGlucuronidaseHumansKlotho ProteinsMaleMiddle AgedMineralsParathyroid HormoneBiomarkersFGF23 protein, humanFibroblast Growth Factor-23GlucuronidaseKlotho ProteinsMineralsParathyroid HormonePhosphatesParathyroid hormonePhosphateSoluble α-klotho

Identifiers

PMID31774122
PMCPMC7341480
OpenAlexW2990368344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.