Evidence map›Paper›PMID 31774030›Full record

ArticleJournal of neurotrauma2020

Extracellular Vesicles Mediate Neuroprotection and Functional Recovery after Traumatic Brain Injury.

Min Kyoung Sun, Austin P Passaro, Charles-Francois Latchoumane, Samantha E Spellicy, Michael Bowler, Morgan Goeden, William J Martin, Philip V Holmes, Steven L Stice, Lohitash Karumbaiah

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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  20. mNSCs overexpressingiScience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Min Kyoung SunRegenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.
Austin P PassaroRegenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.
Charles-Francois LatchoumaneRegenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.
Samantha E SpellicyRegenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.
Michael BowlerDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.
Morgan GoedenDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.
William J MartinAnimal Health Research Center, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Philip V HolmesInterdisciplinary Neuroscience Program, University of Georgia, Athens, Georgia, USA.
Steven L SticeRegenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.
Lohitash KarumbaiahRegenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.
University of Georgia · US

Funding

Creating Endogenous Stem Cell Niches to Promote Functional Brain Repair Post-TBIR01NS099596 · NINDS · UNIVERSITY OF GEORGIA · PI KARUMBAIAH, LOHITASH · 2017 to 2021
$1.6M
6 · The paper itself

Abstract

The lack of effective therapies for moderate-to-severe traumatic brain injuries (TBIs) leaves patients with lifelong disabilities. Neural stem cells (NSCs) have demonstrated great promise for neural repair and regeneration. However, direct evidence to support their use as a cell replacement therapy for neural injuries is currently lacking. We hypothesized that NSC-derived extracellular vesicles (NSC EVs) mediate repair indirectly after TBI by enhancing neuroprotection and therapeutic efficacy of endogenous NSCs. We evaluated the short-term effects of acute intravenous injections of NSC EVs immediately following a rat TBI. Male NSC EV-treated rats demonstrated significantly reduced lesion sizes, enhanced presence of endogenous NSCs, and attenuated motor function impairments 4 weeks post-TBI, when compared with vehicle- and TBI-only male controls. Although statistically not significant, we observed a therapeutic effect of NSC EVs on brain lesion volume, nestin expression, and behavioral recovery in female subjects. Our study demonstrates the neuroprotective and functional benefits of NSC EVs for treating TBI and points to gender-dependent effects on treatment outcomes, which requires further investigation.

Indexed as

AnimalsBrain Injuries, TraumaticCell MovementExtracellular VesiclesFemaleHumansInjections, IntravenousMaleNeural Stem CellsNeuroprotectionRatsRats, Sprague-DawleyRecovery of FunctionStem Cell Transplantationextracellular vesiclesneural stem cellneuroprotectionTBI

Identifiers

PMID31774030
PMCPMC7249471
OpenAlexW2991058219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.