ArticleBrain and behavior2020
Reconfiguration of large-scale functional connectivity in patients with disorders of consciousness.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping fMRI research in disorders of consciousness: a bibliometric study.Frontiers in neurologyPooled it
- Neuroimaging of Disorder of Consciousness: From Brain Network Mechanisms to Clinical Translation.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Decrease and recovery of integrated information Φ during anesthesia and sleep on human functional magnetic resonance imaging.Neuroscience of consciousness · 2025Article
- Re-awakening the brain: Forcing transitions in disorders of consciousness by external in silico perturbation.PLoS computational biology · 2024Article
- Neuroimaging in Disorders of Consciousness and Recovery.Physical medicine and rehabilitation clinics of North America · 2024Review
- Challenges in the measurement and interpretation of dynamic functional connectivity.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Prognosis of consciousness disorders in the intensive care unit.Presse medicale (Paris, France : 1983) · 2023Review
- Dysfunctional connectivity as a neurophysiologic mechanism of disorders of consciousness: a systematic review.Frontiers in neuroscience · 2023Review
- Disrupted multi-scale topological organization of directed functional brain networks in patients with disorders of consciousness.Brain communications · 2023Article
- Disturbed functional connectivity and topological properties of the frontal lobe in minimally conscious state based on resting-state fNIRS.Frontiers in neuroscience · 2023Article
- Ascending arousal network connectivity during recovery from traumatic coma.NeuroImage. Clinical · 2020Article
- Reconfiguration of large-scale functional connectivity in patients with disorders of consciousness.Brain and behavior · 2020Article
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Authors and funding
7 authors.
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Abstract
introductionFunctional connectivity alterations within individual resting state networks (RSNs) are linked to disorders of consciousness (DOC). If these alterations influence the interaction quality with other RNSs, then, brain alterations in patients with DOC would be characterized by connectivity changes in the large-scale model composed of RSNs. How are functional interactions between RSNs influenced by internal alterations of individual RSNs? Do the functional alterations induced by DOC change some key properties of the large-scale network, which have been suggested to be critical for the consciousness emergence? Here, we use network analysis to measure functional connectivity in patients with DOC and address these questions. We hypothesized that network properties provide descriptions of brain functional reconfiguration associated with consciousness alterations.
methodsWe apply nodal and global network measurements to study the reconfiguration linked with the disease severity. We study changes in integration, segregation, and centrality properties of the functional connectivity between the RSNs in subjects with different levels of consciousness.
resultsOur analysis indicates that nodal measurements are more sensitive to disease severity than global measurements, particularly, for functional connectivity of sensory and cognitively related RSNs.
conclusionThe network property alterations of functional connectivity in different consciousness levels suggest a whole-brain topological reorganization of the large-scale functional connectivity in patients with DOC.
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