Evidence map›Paper›PMID 31773904›Full record

ArticleObesity (Silver Spring, Md.)2020

Reaching the Tipping Point: Identification of Thresholds at which Visceral Adipose Tissue May Steeply Increase in Youth.

Aaron S Kelly, Alexander M Kaizer, Tyler A Bosch, Kyle D Rudser, Justin R Ryder, Amy C Gross, Lisa S Chow, Claudia K Fox, Donald R Dengel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Clinical Thresholds for Visceral Adiposity Accumulation: A Comparative Analysis in Sex-, Age-, and BMI-Matched Black and White Adults.American journal of human biology : the official journal of the Human Biology Council · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aaron S KellyDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID 0000-0001-8530-107X
Alexander M KaizerDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0003-2334-5514
Tyler A BoschSchool of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA.
Kyle D RudserCenter for Pediatric Obesity Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Justin R RyderDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID 0000-0002-7506-9497
Amy C GrossDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Lisa S ChowDepartment of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID 0000-0002-6210-2307
Claudia K FoxDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Donald R DengelDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Obesity and Energy Metabolism CoreP30DK050456 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BERNLOHR, DAVID A · 1995 to 2015
$17.0M
TRAINING GRANT IN DIABETES, ENDOCRINOLOGY, &METABOLISMT32DK007203 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LISA Senye CHOW, Douglas G Mashek · 1986 to 2026
$4.3M
Enhancing Weight Loss with Financial Incentives in Teens with Severe ObesityR01DK113631 · NIDDK · UNIVERSITY OF MINNESOTA · PI KELLY, AARON S · 2017 to 2021
$3.5M
SMART Use of Medication for the Treatment ofAdolescent Severe ObesityR01DK119456 · NIDDK · UNIVERSITY OF MINNESOTA · PI FOX, CLAUDIA K · 2019 to 2023
$3.2M
Validation of Circulating Endothelial Cells and Microparticles in YouthR01HL110957 · NHLBI · UNIVERSITY OF MINNESOTA · PI KELLY, AARON S · 2012 to 2016
$3.2M
Enhancing Weight Loss Maintenance with GLP-1 in Adolescents with Severe ObesityR01DK105953 · NIDDK · UNIVERSITY OF MINNESOTA · PI KELLY, AARON S · 2015 to 2019
$3.1M
NCATS NIH HHS UL1 TR000114NHLBI NIH HHS R01 HL110957NIDDK NIH HHS P30 DK050456NIDDK NIH HHS R01 DK105953NIDDK NIH HHS R01 DK113631NIDDK NIH HHS T32 DK007203
6 · The paper itself

Abstract

objectiveThis study aimed to determine whether children and adolescents demonstrate, similarly to adults, a threshold of total percent body fat (%BF) above which the slope of visceral adipose tissue (VAT) rises.

methodsThis cross-sectional study included 557 youth, aged 8 to 18 years, with a wide range of BMI values. Dual-energy x-ray absorptiometry was used to determine body composition (including VAT), and fasting blood was collected for measurement of lipids, glucose, insulin, and biomarkers. Segmented linear regression analysis identified the threshold for %BF unadjusted and adjusted for Tanner stage. Linear regression with robust variance estimation compared associations of risk factors and thresholds.

resultsThresholds of %BF were identified by sex (males = 33%, females = 38%), age (< 12 years = 34%; ≥ 12 years = 30%), and race (White/non-Hispanic = 31%; all other races/Hispanic = 38%) above which the slope of VAT was significantly steeper (all P < 0 .001). The percentage of total body fat stored as VAT was higher above versus below these thresholds (all P < 0.001). Above threshold, but not below it, VAT was associated with triglycerides/high-density lipoprotein ratio, insulin, adiponectin, and blood pressure.

conclusionsThe thresholds should be confirmed in longitudinal studies, and they may be useful in identifying youth at increased cardiometabolic risk in need of close clinical monitoring and/or intensive intervention to reduce excess adiposity.

Indexed as

AdiposityAdolescentAdultBody CompositionChildCross-Sectional StudiesFemaleHumansIntra-Abdominal FatMaleObesity

Identifiers

PMID31773904
PMCPMC6925316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.