Evidence map›Paper›PMID 31773444›Full record

ArticleAIDS and behavior2020

Changes in Days of Unhealthy Alcohol Use and Antiretroviral Therapy Adherence, HIV RNA Levels, and Condomless Sex: A Secondary Analysis of Clinical Trial Data.

Derek D Satre, Varada Sarovar, Wendy Leyden, Charles B Hare, Sheryl L Catz, Kendall J Bryant, Emily C Williams, J Carlo Hojilla, Michael A Horberg, Michael J Silverberg

Abstract read
In one paragraph

Article in AIDS and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Derek D SatreDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA. derek.satre@ucsf.edu.ORCID http://orcid.org/0000-0002-4228-1504
Varada SarovarDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Wendy LeydenDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Charles B HareDepartment of Adult and Family Medicine, Kaiser Permanente San Francisco Medical Center, San Francisco, CA, USA.
Sheryl L CatzBetty Irene Moore School of Nursing, University of California at Davis, Sacramento, CA, USA.
Kendall J BryantNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Emily C WilliamsHealth Services Research & Development Center of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound, Seattle, WA, USA.
J Carlo HojillaDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Michael A HorbergMid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlantic States, Rockville, MD, USA.
Michael J SilverbergDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.

Funding

Substance Use Disorders Treatment/Services Research Training ProgramT32DA007250 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Derek D Satre, Janice Y Tsoh · 1991 to 2026
$7.4M
Primary Care-Based Interventions to Reduce Alcohol Use Among HIV Patients, U01AA021997 Admin SupplementU01AA021997 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SATRE, DEREK D, SILVERBERG, MICHAEL J · 2012 to 2017
$2.9M
Mentoring alcohol use intervention research in HIV health care settingsK24AA025703 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Derek D Satre · 2018 to 2026
$1.8M
NIAAA NIH HHS K24 AA025703NIAAA NIH HHS U01 AA021997NIDA NIH HHS T32 DA007250
6 · The paper itself

Abstract

In a sample of people with HIV (PWH) enrolled in an alcohol intervention trial and followed for 12 months, we examined the association of changes in days (i.e., decrease, increase, no change [reference]) of unhealthy drinking (consuming ≥ 4/≥ 5 drinks for women/men) with antiretroviral therapy adherence (≥ 95% adherent), viral suppression (HIV RNA < 75 copies/mL), condomless sex with HIV-negative/unknown status partners, and dual-risk outcome (HIV RNA ≥ 75 copies/mL plus condomless sex). The sample included 566 PWH (96.8% male; 63.1% White; 93.9% HIV RNA < 75 copies/mL) who completed baseline, 6-, and 12-month assessments. Decrease in days of unhealthy drinking was associated with increased likelihood of viral suppression (odds ratio [OR] 3.78; 95% confidence interval [CI] 1.06, 13.51, P = .04) versus no change. Increase in days of unhealthy drinking was associated with increased likelihood of condomless sex (OR 3.13; 95% CI 1.60, 6.12, P < .001). Neither increase nor decrease were associated with adherence or dual-risk outcome. On a continuous scale, for each increase by 1 day of unhealthy drinking in the prior month, the odds of being 95% adherent decreased by 6% (OR 0.94, 95% CI 0.88, 1.00, P = 0.04).

Indexed as

Antiretroviral Therapy, Highly ActiveMedication AdherenceAdultAlcohol DrinkingAnti-Retroviral AgentsClinical Trials as TopicCondomsFemaleHIV InfectionsHumansLongitudinal StudiesMaleRNA, ViralSexual PartnersUnsafe SexViral LoadAnti-Retroviral AgentsRNA, ViralAlcoholAntiretroviral therapy adherenceHIV transmission riskPrimary careViral control

Identifiers

PMID31773444
PMCPMC7406176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.