Evidence map›Paper›PMID 31773365›Full record

ReviewWorld journal of microbiology & biotechnology2019

Recent advances of pH homeostasis mechanisms in Corynebacterium glutamicum.

Jing Guo, Zhenping Ma, Jinshan Gao, Jinhua Zhao, Liang Wei, Jun Liu, Ning Xu

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of microbiology & biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Research on the pathogen causing root rot onFrontiers in microbiology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Genetic Basis ofLife (Basel, Switzerland) · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Growth Response and Recovery ofFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jing GuoTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.
Zhenping MaTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.
Jinshan GaoTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.
Jinhua ZhaoTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.
Liang WeiTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.
Jun LiuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.
Ning XuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China. xu_n@tib.cas.cn.ORCID http://orcid.org/0000-0002-4123-7827
Chinese Academy of Sciences · CN

Funding

National Key Research and Development Program of China 2018YFA0901000National Natural Science Foundation of China 31801526National Natural Science Foundation of China 31972061Natural Science Foundation of Tianjin City 17JCQNJC09600Natural Science Foundation of Tianjin City 17JCYBJC24000
6 · The paper itself

Abstract

Corynebacterium glutamicum is generally regarded as a safe microorganism, and widely used in the large-scale production of various amino acids and organic acids, such as L-glutamate, L-lysine and succinic acid. During the process of industrial fermentation, C. glutamicum is usually exposed to varying environmental stresses, such as variations in pH, salinity, temperature, and osmolality. Among them, pH fluctuations are regarded as one of the most frequent environmental stresses in microbial fermentation. In this review, we summarize the current knowledge of pH homeostasis mechanisms adopted by C. glutamicum for coping with low acidic pH and high alkaline pH stresses. Facing with low pH environments, C. glutamicum develops a variety of strategies to maintain intracellular pH homeostasis, such as lowering intracellular reactive oxygen species, the improvement of potassium transport, the regulation of mycothiol-related pathways, as well as the repression of sulfur assimilation. While during alkaline pH stresses, the Mrp-type Na

Indexed as

HomeostasisHydrogen-Ion ConcentrationAcidsAdaptation, BiologicalAlkaliesCarboxy-LyasesCell MembraneCorynebacterium glutamicumDrug ResistanceGlutamic AcidLysineMetabolic EngineeringMetabolic Networks and PathwaysProtonsReactive Oxygen SpeciesStress, PhysiologicalAcidsAlkaliesCarboxy-LyasesGlutamic AcidLysineProtonsReactive Oxygen SpeciesSuccinic AcidSulfurAcid-alkaline resistanceCorynebacterium glutamicumMetabolic engineeringpH homeostasis

Identifiers

PMID31773365
OpenAlexW2989571061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.