SynthesisCurrent neurology and neuroscience reports2019
Can Salient Stimuli Enhance Responses in Disorders of Consciousness? A Systematic Review.
Synthesis in Current neurology and neuroscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Care pathways for individuals with post-anoxic disorder of consciousness (CaPIADoC): an inter-society Consensus Conference.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Pupil constrictions to subjective brightness as a gateway to probe consciousness in non communicating patients.Scientific reports · 2025Article
- Hemodynamic responses to emotional auditory stimuli in patients with prolonged disorders of consciousness: an fNIRS study.Frontiers in neurology · 2025Article
- The social and family evaluation (SAFE) scale for caregivers of individuals with disorders of consciousness: preliminary results.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Family caregivers improve the diagnostic accuracy of disorders of consciousness: from remote to near-bed auditory stimulation.European journal of physical and rehabilitation medicine · 2024Article
- Covert Tracking to Immersive Stimuli in Traumatic Brain Injury Subjects With Disorders of Consciousness.Journal of neurotrauma · 2024Article
- Individualized music induces theta-gamma phase-amplitude coupling in patients with disorders of consciousness.Frontiers in neuroscience · 2024Article
- International survey on the implementation of the European and American guidelines on disorders of consciousness.Journal of neurology · 2024Article
- Clinical Decision on Disorders of Consciousness After Acquired Brain Injury: Stepping Forward.Neuroscience bulletin · 2023Review
- Analyzing and computing humans by means of the brain using Brain-Computer Interfaces - understanding the user - previous evidence, self-relevance and the user's self-concept as potential superordinate human factors of relevance.Frontiers in human neuroscience · 2023Review
- New Behavioral Signs of Consciousness in Patients with Severe Brain Injuries.Seminars in neurology · 2022Article
- Towards consensus on visual pursuit and visual fixation in patients with disorders of consciousness. A Delphi study.Journal of neurology · 2022Review
- Importance, limits and caveats of the use of "disorders of consciousness" to theorize consciousness.Neuroscience of consciousness · 2021Review
- Auditory Stimulation Modulates Resting-State Functional Connectivity in Unresponsive Wakefulness Syndrome Patients.Frontiers in neuroscience · 2021Article
- The impact of temporal distribution on fear extinction learning.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewDiagnostic classification of patients with disorders of consciousness (DoC) is based on clinician's observation of volitional behaviours. However, patients' caregivers often report higher levels of responsiveness with respect to those observed during the clinical assessment. Thus, increasing efforts have been aimed at comprehending the effects of self-referential and emotional stimuli on patients' responsiveness. Here we systematically reviewed the original experimental studies that compared behavioural and electrophysiological responses with salient vs. neutral material in patients in vegetative state/unresponsive wakefulness syndrome or in minimally conscious state. RECENT
findingsMost of the reviewed studies showed that salient stimuli (i.e. patient's own or familiar faces, patient's own name, and familiar voices) seem to elicit a higher amount of behavioural or electrophysiological responses with respect to neutral pictures or sounds. Importantly, a quite high percentage of patients seem to respond to salient stimuli only. The present review could foster use of personally salient stimuli in assessing DoC. However, the low overall quality of evidence and some limitations in the general reviewing process might induce caution in transferring these suggestions into clinical practice.
Indexed as
Identifiers
31773300What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.