Evidence map›Paper›PMID 31773257›Full record

ArticleInternational journal of colorectal disease2020

Characteristics and prognosis of isolated small-bowel Crohn's disease.

Juan Du, Haojie Du, Hongtan Chen, Lingyan Shen, Bingling Zhang, Weiwei Xu, Zhongchen Zhang, Chunxiao Chen

Abstract read
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In one paragraph

Article in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  7. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juan DuDepartment of Gastroenterology, Zhejiang University School of Medicine First Affiliated Hospital, #79 Qingchun Road, Hangzhou, 310003, Zhejiang Province, China.
Haojie DuDepartment of Gastroenterology, Zhejiang University School of Medicine First Affiliated Hospital, #79 Qingchun Road, Hangzhou, 310003, Zhejiang Province, China.
Hongtan ChenDepartment of Gastroenterology, Zhejiang University School of Medicine First Affiliated Hospital, #79 Qingchun Road, Hangzhou, 310003, Zhejiang Province, China.
Lingyan ShenDepartment of Gastroenterology, Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang, China.
Bingling ZhangDepartment of Gastroenterology, Zhejiang University School of Medicine First Affiliated Hospital, #79 Qingchun Road, Hangzhou, 310003, Zhejiang Province, China.
Weiwei XuDepartment of Endocrinology, Zhejiang University School of Medicine First Affiliated Hospital, Zhejiang, China.
Zhongchen ZhangDepartment of Gastroenterology, Wenling First People's Hospital, Wenling, China.
Chunxiao ChenDepartment of Gastroenterology, Zhejiang University School of Medicine First Affiliated Hospital, #79 Qingchun Road, Hangzhou, 310003, Zhejiang Province, China. 1184003@zju.edu.cn.

Funding

Major Science and Technology Project of Medical and Health of Zhejiang Province of China WKJ-ZJ-1516
6 · The paper itself

Abstract

backgroundPrevious studies suggest that Crohn's disease (CD) with both small bowel and colon involvement is more serious than colonic CD. However, clinical features of isolated small-bowel CD have not been fully investigated.

methodsIn this retrospective case-control study, 89 patients were divided into two groups according to capsule endoscopy, ileocolonoscopy, and enhanced computed tomography results. The case group was isolated small-bowel CD (n = 50) and the control group was CD with both small bowel and colon involvement (n = 39). We collected data of the patients and analyze it.

resultsIn univariate analysis, isolated small-bowel CD group had higher percentage of stricture, Lewis score, platelet, plateletcrit and lower Harvey-Bradshaw index, high-sensitivity C-reactive protein, and erythrocyte sedimentation rate. In multivariable analysis, it had lower Harvey-Bradshaw index (p = 0.000), which meaned relatively mild symptoms. However, it had higher Lewis score (p = 0.007), which meaned more serious small-bowel inflammation. The Kaplan-Meier survival curve also suggested that isolated small-bowel CD patients were more likely to accept partial small intestinal resection surgery (p = 0.029).

conclusionsIsolated small-bowel CD is easily overlooked for milder clinical symptoms and relatively limited lessions, but severe small-bowel histological injury results in owing worse clinical outcomes. Clinicians should pay more attention to the isolated small-bowel CD and take aggressive intervention during therapy.

Indexed as

AdolescentAdultAgedCase-Control StudiesChildColonColonoscopyCrohn DiseaseDisease-Free SurvivalFemaleHumansIntestine, SmallMaleMiddle AgedProbabilityPrognosisCapsule endoscopyColonInflammatory bowel diseaseSmall bowel

Identifiers

PMID31773257

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.