Evidence map›Paper›PMID 31773188›Full record

ArticleNeuroradiology2020

Altered Granger causality connectivity within motor-related regions of patients with Parkinson's disease: a resting-state fMRI study.

Li Hao, Zhao Sheng, Wang Ruijun, He Zhi Kun, Zhang Peng, Hong Yu

Abstract read
PubMed Publisher
In one paragraph

Article in Neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Dysfunction of motor cortices in Parkinson's disease.Cerebral cortex (New York, N.Y. : 1991) · 2024
    Review
  4. Article
  5. The alterations of spontaneous neural activities and white matter microstructures in anti-N-methyl-D-aspartate receptor encephalitis: a resting-state fMRI and DTI study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Li HaoDepartment of Imaging Center, The First Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Zhao ShengDepartment of Imaging Center, The First Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Wang RuijunDepartment of Imaging Center, The First Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
He Zhi KunCT Room, People's Hospital of Wu La Te Qian Qi, Bayan Nuo'er, 014400, Inner Mongolia, China.
Zhang PengDepartment of Imaging Center, The First Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Hong YuDepartment of Imaging Center, The First Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China. hongyu017@163.com.ORCID http://orcid.org/0000-0003-0107-9489
Inner Mongolia Medical University · CNPeople's Hospital of Xinjiang Uygur Autonomous Region · CN

Funding

Inner Mongolia University for Nationalities (CN) ZYFYZD014Jiangsu Agricultural Science and Technology Independent Innovation Fund (CN) NJZY17115
6 · The paper itself

Abstract

purposeAlthough numerous clinical neuroimaging studies have demonstrated that there are functional abnormalities of motor-related regions in patients with Parkinson's disease (PD) by resting-state functional magnetic resonance imaging (fMRI), little studies have explored the causal interactions within these motor-related regions. The present study aimed to examine Granger causality connectivity patterns within motor-related regions in PD patients.

methodsResting-state fMRI was conducted to investigate the causal connectivity differences within motor-related regions between 17 PD patients and 17 matched healthy controls. Subsequently, the relationship between the Unified Parkinson's Disease Rating Scale scores and causal connectivity values within motor-related regions was examined in PD patients.

resultsAn increased causal connectivity from the left premotor cortex (PMC) to right primary motor cortex (M1) was found in PD patients compared with that of healthy controls. Also, increased causal flow from the PMC to M1 was negatively correlated with motor scores.

conclusionPD patients have abnormal causal connectivity in specific motor-related regions, which may reflect a compensatory role of motor deficits in PD patients.

Indexed as

Brain MappingCase-Control StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMotor ActivityMotor CortexNeural PathwaysParkinson DiseaseRestGranger causality analysisMotor networksParkinson’s diseaseResting-state fMRI

Identifiers

PMID31773188
OpenAlexW2989868508

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.