ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Diarrhea as a Potential Cause and Consequence of Reduced Gut Microbial Diversity Among Undernourished Children in Peru.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of associations between gut microbiome composition and stunting in under-five children.NPJ biofilms and microbiomes · 2024Pooled it
- Lactiplantibacillus plantarum P9 for chronic diarrhea in young adults: a large double-blind, randomized, placebo-controlled trial.Nature communications · 2024Trial
- Review
- A Latin American perspective on microbiome research.Nature communications · 2025Review
- The Gut Microbiota of Peruvian Children Under the Age of Two During the Complementary Feeding Period.International journal of environmental research and public health · 2025Article
- The South American MicroBiome Archive (saMBA): enriching the microbiome field by studying neglected populations.Nature communications · 2025Article
- Expanding the human gut microbiome atlas of Africa.Nature · 2025Article
- Baseline gut microbiome alpha diversity predicts chemotherapy-induced gastrointestinal symptoms in patients with breast cancer.NPJ breast cancer · 2024Article
- Manipulating a host-native microbial strain compensates for low microbial diversity by increasing weight gain in a wild bird population.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Gut microbiota patterns associated with duration of diarrhea in children under five years of age in Ethiopia.Nature communications · 2024Article
- Microbial imbalance in Chinese children with diarrhea or constipation.Scientific reports · 2024Article
- Infant diarrheal disease in rhesus macaques impedes microbiome maturation and is linked to uncultured Campylobacter species.Communications biology · 2024Article
- Gut microbiota absence and transplantation affect diarrhea: an investigation in the germ-free piglet model.Animal biotechnology · 2023Article
- Summer diarrhea in children: a monocentric French epidemiological observational study.Scientific reports · 2023Observational
- The gut microbiome and early-life growth in a population with high prevalence of stunting.Nature communications · 2023Article
- Altered Faecal Microbiota Composition and Structure of Ghanaian Children with Acute Gastroenteritis.International journal of molecular sciences · 2023Article
- Effects of prebiotics on the gut microbiotaFrontiers in microbiology · 2023Article
- Diarrheal-associated gut dysbiosis in cancer and inflammatory bowel disease patients is exacerbated byFrontiers in cellular and infection microbiology · 2023Article
- Dynamics of the Gut Microbiome inmSystems · 2022Article
- Unlocking the Potential of the Human Microbiome for Identifying Disease Diagnostic Biomarkers.Diagnostics (Basel, Switzerland) · 2022Review
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12 authors.
Funding
Abstract
backgroundDetrimental effects of diarrhea on child growth and survival are well documented, but details of the underlying mechanisms remain poorly understood. Recent evidence demonstrates that perturbations to normal development of the gut microbiota in early life may contribute to growth faltering and susceptibility to related childhood diseases. We assessed associations between diarrhea, gut microbiota configuration, and childhood growth in the Peruvian Amazon.
methodsGrowth, diarrhea incidence, illness, pathogen infection, and antibiotic exposure were assessed monthly in a birth cohort of 271 children aged 0-24 months. Gut bacterial diversity and abundances of specific bacterial taxa were quantified by sequencing 16S rRNA genes in fecal samples collected at 6, 12, 18, and 24 months. Linear and generalized linear models were used to determine whether diarrhea was associated with altered microbiota and, in turn, if features of the microbiota were associated with the subsequent risk of diarrhea.
resultsDiarrheal frequency, duration, and severity were negatively associated with bacterial diversity and richness (P < .05). Children born stunted (length-for-age z-score [LAZ] ≤ -2) who were also severely stunted (LAZ ≤ -3) at the time of sampling exhibited the greatest degree of diarrhea-associated reductions in bacterial diversity and the slowest recovery of bacterial diversity after episodes of diarrhea. Increased bacterial diversity was predictive of reduced subsequent diarrhea from age 6 to 18 months.
conclusionsPersistent, severe growth faltering may reduce the gut microbiota's resistance and resilience to diarrhea, leading to greater losses of diversity and longer recovery times. This phenotype, in turn, denotes an increased risk of future diarrheal disease and growth faltering.
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