ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Gut Microbiota Features Associated With Campylobacter Burden and Postnatal Linear Growth Deficits in a Peruvian Birth Cohort.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Anthropometric and neurocognitive consequences of Campylobacter, enterotoxigenic Escherichia coli, and norovirus: A systematic review.PLoS neglected tropical diseases · 2025Pooled it
- Systematic review of associations between gut microbiome composition and stunting in under-five children.NPJ biofilms and microbiomes · 2024Pooled it
- Gut microbiome dynamics in acute infectious diarrhea: A conceptual framework from acute dysbiosis toward precision restoration (Review).Experimental and therapeutic medicine · 2026Review
- Prevalence, species diversity, and antimicrobial resistance profiles ofMicrobiology spectrum · 2026Article
- Segmented filamentous bacteria are worldwide human gut commensals.Nature communications · 2026Article
- Gut microbiome dysbiosis and functional alterations inGut microbes reports · 2026Article
- The epidemiology and impact of persistentEClinicalMedicine · 2024Article
- Gut microbiota patterns associated with duration of diarrhea in children under five years of age in Ethiopia.Nature communications · 2024Article
- Capturing clinically relevantMicrobial genomics · 2024Article
- Campylobacter jejuni virulence factors: update on emerging issues and trends.Journal of biomedical science · 2024Review
- Genomic resistant determinants of multidrug-resistant Campylobacter spp. isolates in Peru.Journal of global antimicrobial resistance · 2024Article
- Current Understanding ofCurrent tropical medicine reports · 2024Article
- Infant diarrheal disease in rhesus macaques impedes microbiome maturation and is linked to uncultured Campylobacter species.Communications biology · 2024Article
- Diversity and prevalence of zoonotic infections at the animal-human interface of primate trafficking in Peru.PloS one · 2024Article
- Campylobacter in Africa - A specific viewpoint.European journal of microbiology & immunology · 2023Review
- Prevalence and Load of the Campylobacter Genus in Infants and Associated Household Contacts in Rural Eastern Ethiopia: a Longitudinal Study from the Campylobacter Genomics and Environmental Enteric Dysfunction (CAGED) Project.Applied and environmental microbiology · 2023Article
- The Epidemiology of Sapovirus in the Etiology, Risk Factors, and Interactions of Enteric Infection and Malnutrition and the Consequences for Child Health and Development Study: Evidence of Protection Following Natural Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Shotgun metagenomics of fecal samples from children in Peru reveals frequent complex co-infections with multiple Campylobacter species.PLoS neglected tropical diseases · 2022Article
- HIV and Mediterranean Zoonoses: A Review of the Literature.Infectious disease reports · 2022Review
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11 authors at 3 institutions in 1 country.
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Abstract
backgroundCampylobacter infection is associated with impaired growth of children, even in the absence of symptoms. To examine the underlying mechanisms, we evaluated associations between Campylobacter infection, linear growth, and fecal microbial community features in a prospective birth cohort of 271 children with a high burden of diarrhea and stunting in the Amazonian lowlands of Peru.
methodsCampylobacter was identified using a broadly reactive, genus-specific enzyme-linked immunosorbent assay. 16S rRNA-based analyses were used to identify bacterial taxa in fecal samples at ages 6, 12, 18, and 24 months (N = 928). Associations between infection, growth, and gut microbial community composition were investigated using multiple linear regression adjusting for within-child correlations, age, and breastfeeding. Indicator species analyses identified taxa specifically associated with Campylobacter burden.
resultsNinety-three percent (251) of children had Campylobacter present in asymptomatic fecal samples during the follow-up period. A 10% increase in the proportion of stools infected was associated with mean reductions of 0.02 length-for-age z scores (LAZ) at 3, 6, and 9 months thereafter (P < .01). We identified 13 bacterial taxa indicative of cumulative Campylobacter burden and 14 taxa significantly associated with high or low burden of enteroaggregative Escherichia coli, norovirus, or Giardia.
conclusionsCampylobacter infection is common in this cohort and associated with changes in microbial community composition. These results support the notion that disruptions to the fecal microbiota may help explain the observed effects of asymptomatic infections on growth in early life.
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