Evidence map›Paper›PMID 31773101›Full record

ArticlePrecision nanomedicine2018

SPECIFIC MOLECULAR RECOGNITION AS A STRATEGY TO DELINEATE TUMOR MARGIN USING TOPICALLY APPLIED FLUORESCENCE EMBEDDED NANOPARTICLES.

Shawn Barton, Bo Li, Michael Siuta, Janve Vaibhav, Jessica Song, Clinton M Holt, Takumi Tomono, Masami Ukawa, Hironori Kumagai, Etsuo Tobita and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Precision nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Shawn BartonVanderbilt University Institute of Imaging Science, Nashville, TN.
Bo LiVanderbilt University Institute of Imaging Science, Nashville, TN.
Michael SiutaVanderbilt University Institute of Imaging Science, Nashville, TN.
Janve VaibhavVanderbilt University Institute of Imaging Science, Nashville, TN.
Jessica SongVanderbilt University Institute of Imaging Science, Nashville, TN.
Clinton M HoltVanderbilt University Institute of Imaging Science, Nashville, TN.
Takumi TomonoFaculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan.
Masami UkawaFaculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan.
Hironori KumagaiAdvanced Materials R&D Laboratory, ADEKA Corp., Tokyo, Japan.
Etsuo TobitaAdvanced Materials R&D Laboratory, ADEKA Corp., Tokyo, Japan.
Kevin WilsonVanderbilt University Institute of Imaging Science, Nashville, TN.
Shinji SakumaFaculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan.
Wellington PhamVanderbilt University Institute of Imaging Science, Nashville, TN.
Vanderbilt University · USSetsunan University · JPVanderbilt Health · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Multifunctional Nanoparticles for Image-Guided Vaccine Delivery in CancerR01CA160700 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHAM, WELLINGTON · 2012 to 2015
$1.3M
LSM880-Airyscan Confocal Microscope for Large Shared ResourceS10OD021630 · OD · VANDERBILT UNIVERSITY · PI WELLS, K. SAM · 2016 to 2016
$560k
Confocal Microscope for Live Embryo Imaging in a Shared Resource FacilityS10RR027396 · NCRR · VANDERBILT UNIVERSITY · PI PRINCE, LAWRENCE S · 2010 to 2010
$460k
NCI NIH HHS R01 CA160700NCRR NIH HHS S10 RR027396NIGMS NIH HHS T32 GM007347NIH HHS S10 OD021630
6 · The paper itself

Abstract

The Thomsen-Friedenreich (TF) antigen is a tumor-associated antigen consistently expressed on the apical surface of epithelial-based cancer cells, including pancreatic cancer. In this work, we report the development of multimodal imaging probe, the tripolymer fluorescent nanospheres, whose surface was fabricated with peanut agglutinin (PNA) moieties as TF molecular recognition molecules. Here, we demonstrate that the probe is able to detect TF antigen in human pancreatic cancer tissues and differentiate from normal tissue. What is most noteworthy regarding the probe is its ability to visualize tumor margins defined by epithelial TF antigen expression. Further,

Identifiers

PMID31773101
PMCPMC6879183
OpenAlexW2914499282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.