ArticleAnimal models and experimental medicine2019
The animal cachexia score (ACASCO).
Article in Animal models and experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Robust Scoring System to Evaluate Animal Well-Being in Murine (Mus musculus) Orthotopic Breast Cancer and Ovarian Cancer Models.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice.Nature metabolism · 2025Article
- Investigation into the causes of mortality in cetaceans and sirenian populations in the Andaman Sea, Thailand: A retrospective analysis spanning 2018-2023.Veterinary world · 2024Article
- Characterization of a Cancer-Induced Bone Pain Model for Use as a Model of Cancer Cachexia.Current issues in molecular biology · 2024Article
- Low-dose orthotopic cancer implantation permits measurement of longitudinal functional changes associated with cachexia.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Pathological beige remodeling induced by cancer cachexia depends on the disease severity and involves mainly the trans-differentiation of mature white adipocytes.bioRxiv : the preprint server for biology · 2023Article
- Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia.Cell metabolism · 2023Article
- Variable body and tissue weight reporting in preclinical cachexia literature may alter study outcomes and interpretation.Disease models & mechanisms · 2023Article
- Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia.bioRxiv : the preprint server for biology · 2023Article
- IFIT2-depleted metastatic oral squamous cell carcinoma cells induce muscle atrophy and cancer cachexia in mice.Journal of cachexia, sarcopenia and muscle · 2022Article
- Review
- The animal cachexia score (ACASCO).Animal models and experimental medicine · 2019Article
- Murine cancer cachexia models replicate elevated catabolic pembrolizumab clearance in humans.JCSM rapid communicationsArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNone of the published studies involving cancer cachexia experimental models have included a measure of the severity of the syndrome like the scoring system previously developed for human subjects. The aim of the present investigation was to define and validate a cachexia score usable in both rat and mouse tumor models.
methodsIn order to achieve this goal, we included in the study one rat model (Yoshida AH-130ascites hepatoma) and two mouse models (Lewis lung carcinoma and Colon26 carcinoma). The Animal cachexia score (ACASCO) includes five components: (a) body and muscle weight loss, (b) inflammation and metabolic disturbances, (c) physical performance, (d) anorexia, and (e) quality of life measured using discomfort symptoms and behavioral tests.
resultsUsing the ACASCO values, three cut-off values were estimated by applying hierarchical cluster analysis. Four groups were originally described, one exactly below the observed mean, a second exactly over the mean, and two other groups adjusted to every cue (inferior and superior). The three cut-off values were estimated through maximization of the classification function. This was accomplished by using a similarity matrix based on the metric properties of the variables and assuming multinormal distribution. The results show that the four groups were: no cachexia, mild cachexia, moderate cachexia and advanced cachexia.
conclusionsThe results obtained allow us to conclude that the score could be very useful as an endpoint in pre-clinical studies involving therapeutic strategies for cancer cachexia. The potential usefulness of ACASCO relates to the primary endpoint in pre-clinical cancer cachexia drug evaluations.
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