Evidence map›Paper›PMID 31772995›Full record

ArticleInternational journal of particle therapy2017

Clinical and Radiologic Outcomes in Adults and Children Treated with Pencil-Beam Scanning Proton Therapy for Low-Grade Glioma.

Shahed N Badiyan, Stephan Ulmer, Frank J Ahlhelm, Anna S M Fredh, Ulrike Kliebsch, Gabriele Calaminus, Alessandra Bolsi, Francesca Albertini, Dominic Leiser, Beate Timmermann and 4 more

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of particle therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Shahed N BadiyanDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.
Stephan UlmerMedical Radiological Institute, Zurich, Switzerland.
Frank J AhlhelmDepartment of Radiology, Cantonal Hospital Baden, Baden, Switzerland.
Anna S M FredhCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland.
Ulrike KliebschCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland.
Gabriele CalaminusDepartment of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.
Alessandra BolsiCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland.
Francesca AlbertiniCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland.
Dominic LeiserUniversity Hospital Inselspital, Bern, Switzerland.
Beate TimmermannClinic for Particle Therapy, West German Proton Center, University Hospital Essen, Germany.
Robert S MalyapaCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland.
Ralf SchneiderCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland.
Antony J LomaxCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland.
Damien C WeberCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland.
Paul Scherrer Institute · CHKantonsspital Baden · CHUniversity Hospital Münster · DEUniversity Hospital of Bern · CHUniversity of Maryland, Baltimore · USWest German Heart and Vascular Center Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe assessed clinical and radiologic outcomes in adults and children with low-grade glioma (LGG) of the brain treated with pencil-beam scanning (PBS) proton therapy (PT). MATERIALS AND

methodsBetween 1997 and 2014, 28 patients were treated with PBS PT, 20 (71%) of whom were younger than 18 years. Median age at start of PT was 12.3 years (range, 2.2-53.0 years). Nine patients (32%) underwent at least a subtotal resection; 12 (43%) underwent biopsy; and 7 (25%) were diagnosed radiographically. Twelve patients (43%) had grade II and 9 (32%) had grade I gliomas. Eleven patients (39%) received chemotherapy before PT. A median dose of 54 Gy (relative biologic effectiveness) was administered. Radiologic response to PT was determined using the Response Evaluation Criteria in Solid Tumors (RECIST). Eight domains of quality of life (QoL) for 16 pediatric patients were assessed prospectively by patients' parents using the pediatric QoL proxy questionnaire. Progression-free survival and overall survival (OS) were estimated by the Kaplan-Meier method. Median follow-up was 42.1 months for living patients.

resultsTen patients (36%) developed local, clinical failure. Three patients (11%) died, all of tumor progression. Radiographic tumor response by RECIST was evaluable in 11 patients: 9 (82%) with stable disease, 1 (9%) with partial response, and 1 (9%) with complete response to PT. Three-year OS and progression-free survival were 83.4% and 56.0%, respectively. No ≥ grade III acute toxicities were observed. Grade III, late radiation necrosis developed in 1 patient (4%). No appreciable change in pediatric QoL proxy scores in children was noted in any of the 8 domains at any time point.

conclusionTreatment with PBS PT is effective for LGG, with minimal acute toxicity and, in children, no appreciable decline in QoL. More patients and longer follow-up are needed to determine the long-term efficacy and toxicity of PT for LGG.

Indexed as

low-grade gliomapediatricpencil-beam scanningproton therapyquality of life

Identifiers

PMID31772995
PMCPMC6871558
OpenAlexW2613028707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.