ArticleBioMed research international2019
Interleukin-6 and Interleukin-15 as Possible Biomarkers of the Risk of Autoimmune Diabetes Development.
Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Effects of High-Intensity Interval Training on Inflammatory Biomarkers in Patients with Type 2 Diabetes. A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Hyperglycemia and Lung Cancer-A Possible Relationship.Diagnostics (Basel, Switzerland) · 2025Review
- Distinct cytokine profiles in plasma and tears highlight ophthalmologic inflammation in type 2 diabetes without retinopathy.Frontiers in medicine · 2025Article
- Clinical importance of cytokine (IL-6, IL-8, and IL-10) and vitamin D levels among patients with Type-1 diabetes.Scientific reports · 2024Article
- Molecular targets and mechanisms ofWorld journal of diabetes · 2023Article
- Hepatic T-cell senescence and exhaustion are implicated in the progression of fatty liver disease in patients with type 2 diabetes and mouse model with nonalcoholic steatohepatitis.Cell death & disease · 2023Article
- Differential Roles of Interleukin-6 in Severe Acute Respiratory Syndrome-Coronavirus-2 Infection and Cardiometabolic Diseases.Cardiology discovery · 2023Article
- Elevated IL-6 plasma levels are associated with GAD antibodies-associated autoimmune epilepsy.Frontiers in cellular neuroscience · 2023Article
- Latent autoimmune diabetes in adults in China.Frontiers in immunology · 2022Review
- Innate immunity in latent autoimmune diabetes in adults.Diabetes/metabolism research and reviews · 2022Review
- Anti-diabetics and antimicrobials: Harmony of mutual interplay.World journal of diabetes · 2021Review
- Therapeutic approaches targeting molecular signaling pathways common to diabetes, lung diseases and cancer.Advanced drug delivery reviews · 2021Review
- β-cell self-destruction and extremely complicated and still unknown etiopathogenesis of type 1 diabetes.Pediatric endocrinology, diabetes, and metabolism · 2021Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of our study was to assay circulating interleukin-15 (IL-15) and interleukin-6 (IL-6) levels and insulin resistance measured by two different methods in newly diagnosed autoimmune diabetes (AD) patients, their I° relatives, and healthy controls. MATERIAL AND
methodsThe group studied consisted of 54 patients with AD (28 with Latent Autoimmune Diabetes in Adults (LADA) and 26 with type 1 diabetes (T1D)), 70 first-degree relatives, and 60 controls. IL-6, IL-15, and anti-islet antibodies concentrations were measured by ELISA method. Homeostatic model assessment-insulin resistance (HOMAIR) and estimated glucose disposal rate (eGDR) were calculated.
resultsThe patients with AD had significantly higher IL-15, IL-6, and HOMAIR and lower eGDR than the controls (
conclusionsSignificantly higher IL-15 and IL-6 concentrations, HOMAIR, and markedly lower eGDR in newly diagnosed AD patients and first-degree relatives with positive anti-islet antibodies might suggest the role of these pro-inflammatory cytokines and insulin resistance in the pathogenesis of autoimmune diabetes. IL-15 and IL-6 might be used as biomarkers of the risk of autoimmune diabetes development, in particular IL-15 for LADA. Both methods of IR measurement appear equally useful for calculating insulin resistance in autoimmune diabetes.
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