Evidence map›Paper›PMID 31772926›Full record

ArticleEpidemiology, biostatistics and public health2019

Bayesian model averaging: improved variable selection for matched case-control studies.

Yi Mu, Isaac See, Jonathan R Edwards

Abstract read
In one paragraph

Article in Epidemiology, biostatistics and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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  7. Metacognition, public health compliance, and vaccination willingness.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

3 authors.

Yi MuDivision of Healthcare Quality and Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Center for Disease Control and Prevention.
Isaac SeeDivision of Healthcare Quality and Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Center for Disease Control and Prevention.
Jonathan R EdwardsDivision of Healthcare Quality and Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Center for Disease Control and Prevention.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundThe problem of variable selection for risk factor modeling is an ongoing challenge in statistical practice. Classical methods that select one subset of exploratory risk factors dominate the medical research field. However, this approach has been criticized for not taking into account the uncertainty of the model selection process itself. This limitation can be addressed by a Bayesian model averaging approach: instead of focusing on a single model and a few factors, Bayesian model averaging considers all the models with non-negligible probabilities to make inference.

methodsThis paper reports on a simulation study designed to emulate a matched case-control study and compares classical versus Bayesian model averaging selection methods. We used Matthews's correlation coefficient to measure the quality of binary classifications. Both classical and Bayesian model averaging were also applied and compared for the analysis of a matched case-control study of patients with methicillin-resistant

resultsBayesian model averaging outperformed the classical approach with much lower false positive rates and higher Matthew's correlation scores. Bayesian model averaging also produced more reliable and robust effect estimates.

conclusionBayesian model averaging is a conceptually simple, unified approach that produces robust results. It can be used to replace controversial P-values for case-control study in medical research.

Indexed as

Bayesian model averagingGibbs variable selectionmatched case controlmodel selectionZellner’s g-prior

Identifiers

PMID31772926
PMCPMC6879006

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.