Evidence map›Paper›PMID 31772828›Full record

ArticleTranslational vision science & technology2019

Repeatability of Optical Coherence Tomography Angiography in Uveitic Eyes.

Sonny Caplash, Shilpa Kodati, Shuk Kei Cheng, Marib Akanda, Susan Vitale, Ian Thompson, Sapna Gangaputra, H Nida Sen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Observational
  6. International journal of molecular sciences · 2022
    Article
  7. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Sonny CaplashNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Shilpa KodatiBaylor College of Medicine, Cullen Eye Institute, Houston, TX, USA.
Shuk Kei ChengNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Marib AkandaNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Susan VitaleNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Ian ThompsonNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Sapna GangaputraNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
H Nida SenNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
National Eye Institute · USNational Institutes of Health · USBaylor College of Medicine · USVanderbilt Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the intravisit repeatability of optical coherence tomography angiography (OCTA) in a cohort of uveitis patients.

methodsOne hundred ten patients were imaged twice per eye, per visit, using the Zeiss Cirrus HD-OCT Model 5000 device. To calculate choriocapillaris flow void area (CC FV) 6 × 6-mm images were used, and 3 × 3-mm images were used to calculate vessel density (VD) and the foveal avascular zone area (FAZ) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP). Repeatability was measured using Bland-Altman analyses and intraclass correlation coefficients (ICC) with associated coefficient of variation (CV).

resultsThe level of intravisit repeatability differed across indices ranging from moderate to excellent. CC FV had the highest intravisit repeatability with an ICC of 0.980 (95%CI, 0.966-0.989), a CV of 15.9% and Bland-Altman limits of agreement from -0.398 to 0.411 mm

conclusionsThis study demonstrates that OCTA is a reliable tool to quantitatively assess specific indices of vascular structure in uveitis patients with good intravisit repeatability. However, the range of variability for each index should be taken into account when evaluating clinically meaningful changes. TRANSLATIONAL RELEVANCE: The repeatability of the metrics we have described has implications in supporting the development of OCTA-derived quantitative assessments of the retinal and choroidal vasculature in uveitis patients as potential imaging biomarkers.

Indexed as

OCTArepeatabilityuveitis

Identifiers

PMID31772828
PMCPMC6859831
OpenAlexW2987896294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.