ArticleTranslational vision science & technology2019
Observational Clinical Studies of Human Lens Transparency Using the Vision Index Pen.
Article in Translational vision science & technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors at 3 institutions in 1 country.
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Abstract
purposePreventing or delaying the onset of presbyopia and cataract formation remains a challenge. The goal of this study was to establish the utility of the Vision Index Pen (VIP), designed to measure in vivo dynamic light scattering (DLS) from the crystalline lens, in the detection of early cataract or loss of accommodation and to show reproducibility through trials at two independent sites. The gradual loss of transparency of the lens was characterized by the lens crystallin aggregation index (LCX) derived from measured DLS data.
methodsVolunteers in different age groups participated in two independently operated observational clinical studies. All subjects underwent a detailed eye exam and VIP measurement of the intensity correlation of the backscattered light from the lens.
resultsLCX values extracted from DLS data show strong correlation with the aging lens, ranging from 20 at the age of 20 years to over 150 at 60 years. Quantitatively significant changes in the LCX value occur from 35 years to 55 years. LCX values were found to correlate with the loss of accommodation (correlation of -0.563 with
conclusionsResults from two independent observational clinical trials have confirmed the repeatability and reproducibility of the VIP diagnostic device as a viable clinical tool for tracking localized macromolecular changes taking place in the aging lens. Detection of early changes in the crystalline lens can be useful in developing patient-specific prediction models, which can be used to screen patients who may benefit from early therapeutic interventions for delaying the onset of presbyopia and cataract growth. TRANSLATIONAL RELEVANCE: The VIP diagnostic device provides in vivo access to the human lens, enabling characterization of the unfolding and decomposition of long-lived macromolecules.
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