Evidence map›Paper›PMID 31772774›Full record

ArticleInternational journal of nephrology2019

Drug-Related Problems and Associated Factors among Patients Admitted with Chronic Kidney Disease at Jimma University Medical Center, Jimma Zone, Jimma, Southwest Ethiopia: A Hospital-Based Prospective Observational Study.

Aster Wakjira Garedow, Eshetu Mulisa Bobasa, Amare Desalegn Wolide, Fantu Kerga Dibaba, Fanta Gashe Fufa, Birtukan Idilu Tufa, Serkadis Debalke, Kabaye Kumela Goro

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Article in International journal of nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aster Wakjira GaredowJimma University, School of Pharmacy, Jimma, Ethiopia.ORCID https://orcid.org/0000-0001-5159-7247
Eshetu Mulisa BobasaJimma University, School of Pharmacy, Jimma, Ethiopia.
Amare Desalegn WolideJimma University, School of Biomedical Sciences, Jimma, Ethiopia.
Fantu Kerga DibabaJimma University, School of Pharmacy, Jimma, Ethiopia.
Fanta Gashe FufaJimma University, School of Pharmacy, Jimma, Ethiopia.ORCID https://orcid.org/0000-0003-3245-4077
Birtukan Idilu TufaJimma University, School of Midwifery and Nursing, Jimma, Ethiopia.
Serkadis DebalkeJimma University, School of Medical Laboratory, Jimma, Ethiopia.ORCID https://orcid.org/0000-0002-2165-1270
Kabaye Kumela GoroJimma University, School of Pharmacy, Jimma, Ethiopia.ORCID https://orcid.org/0000-0001-6453-9118

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is an alarming rise of chronic kidney disease prevalence globally associated with significant morbidity and mortality necessitating special attention as one of the major growing public health problems. Medication-related problems are common in hospitalized patients including chronic kidney disease and may lead to increase hospital stay and health care cost and augment the risk of morbidity and mortality.

objectiveTo determine prevalence of medication-related problems and associated factors among chronic kidney disease patients admitted to Jimma University Medical Center from April to September 2018.

methodsA hospital-based prospective observational study was conducted among 103 chronic kidney disease patients admitted to Jimma University Medical Center from April to September 2018. Data regarding patient characteristics, medications, diagnosis, length of hospitalization, and laboratory results were collected through review of patients' medical charts. Data were analyzed by using Statistical Package for the Social Sciences (SPSS) version 21.0. Univariate and multivariate logistic regression was utilized to assess the associations between dependent and independent variables. Statistical significance was considered at

resultsOut of 103 chronic kidney disease patients, 81 (78.6%) of patients had MDRs, on average 1.94 ± 0.873 per patient. The rate of overall MRPs was 30.95 per 100 medication orders. The most common MRPs among CKD patients were need additional drug therapy (62 (31%)), nonadherence (40 (20%)), and dose too low (36 (18%)). The most common cause of need additional drug therapy (52 (26%)) was untreated medical conditions; nonadherence (19 (9.5%)) was mostly due to that the patient/caregiver forgets to take/give the medication, and dose too low (29 (14.5%)) was mostly due to that the dose is too low to produce the desired response. Polypharmacy (AOR = 4.695, 95% CI: 1.370-16.091), number of comorbidities (AOR = 3.616, 95% CI: 1.015-1.8741), and stage of CKD (AOR = 3.941, 95% CI: 1.221-12.715) were independent predictors for MRPs.

conclusionsWe have demonstrated that medication-related problems are high among chronic kidney disease patients. Marital statuses, stage of CKD, polypharmacy, and comorbidity were independent predictors for MRPs. Interdisciplinary health professionals should work to decrease the high prevalence of MRPs among chronic kidney disease patients.

Identifiers

PMID31772774
PMCPMC6854244

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.