Observational studyCardiovascular therapeutics2019
New Insights into the Association between Fibrinogen and Coronary Atherosclerotic Plaque Vulnerability: An Intravascular Optical Coherence Tomography Study.
Observational study in Cardiovascular therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Prognostic value of X-box binding protein 1 and phospholipase A2 in myocardial injury after ST-segment elevation myocardial infarction: a prospective observational study.Journal of cardiothoracic surgery · 2026Observational
- C-Reactive Protein-Triglyceride-Glucose Index and Coronary Artery Calcium Progression: A Prospective Cohort Analysis.Clinical cardiology · 2026Observational
- Association between uric acid to high-density cholesterol ratio (UHR) and in-stent neoatherosclerosis: an optical coherence tomography study.BMC cardiovascular disorders · 2026Article
- Associations of Gla-rich protein and interleukin-1β with coronary artery calcification risk in patients with suspected coronary artery disease.Frontiers in endocrinology · 2025Article
- Endothelial dysfunction in chronic obstructive pulmonary disease: an update on mechanisms, assessment tools and treatment strategies.Frontiers in medicine · 2025Review
- Association of fibrinogen-to-albumin ratio in patients with isolated coronary artery ectasia.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Article
- Developing a novel diagnostic model for identifying high-risk plaques in new onset unstable angina pectoris using coronary CT angiography.Frontiers in endocrinology · 2025Article
- The Relationship Between the Fibrinogen-to-Albumin Ratio and Short-Term Mortality in Chinese Patients With Chronic Heart Failure: A Retrospective Cohort Analysis.Cardiology research and practice · 2025Article
- Inflammation Biomarker-Driven Vertical Visualization Model for Predicting Long-Term Prognosis in Unstable Angina Pectoris Patients with Angiographically Intermediate Coronary Lesions.Journal of inflammation research · 2024Article
- Serum total bilirubin and long-term prognosis of patients with new-onset non-ST elevation myocardial infarction: a cohort study.BMC cardiovascular disorders · 2022Article
- Early Diagnosis and Treatment of Coronary Heart Disease with Image Features of Optical Coherence Tomography under Adaptive Segmentation Algorithm.Computational and mathematical methods in medicine · 2022Article
- Fibrinogen and Atherosclerotic Cardiovascular Diseases-Review of the Literature and Clinical Studies.International journal of molecular sciences · 2021Review
- Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches.International journal of molecular sciences · 2021Review
- Magnesium Sulfate Improves Some Risk Factors for Atherosclerosis in Patients Suffering from One or Two Coronary Artery Diseases: A Double-blind Clinical Trial Study.Clinical pharmacology : advances and applications · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFibrinogen levels have been associated with coronary plaque vulnerability in experimental studies. However, it has yet to be determined if serum fibrinogen levels are independently associated with coronary plaque vulnerability as detected by optical coherence tomography (OCT) in patients with coronary heart disease.
methodsPatients with coronary heart disease (CHD) who underwent coronary angiography and OCT in our department from January 2015 to August 2018 were included in this study. Coronary lesions were categorized as ruptured plaque, nonruptured with thin-cap fibroatheroma (TCFA), and nonruptured and non-TCFA. Presence of ruptured plaque and nonruptured with TCFA was considered to be vulnerable lesions. Determinants of coronary vulnerability were evaluated by multivariable logistic regression analyses.
resultsA total of 154 patients were included in this study; 17 patients had ruptured plaques, 15 had nonruptured plaques with TCFA, and 122 had nonruptured plaques with non-TCFA. Results of univariate analyses showed that being male, diabetes, current smoking, high body mass index (BMI), and clinical diagnosis of acute coronary syndrome (ACS) were associated with coronary vulnerability. No significant differences were detected in patient characteristics, coronary angiographic findings, and OCT results between patients with higher and normal fibrinogen. Results of multivariate logistic analyses showed that diabetes and ACS were associated with TCFA, while diabetes, higher BMI, and ACS were associated with plaque rupture.
conclusionsDiabetes, higher BMI, and ACS are independently associated with coronary vulnerability as detected by OCT. Serum fibrinogen was not associated with coronary vulnerability in our cohort.
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