Evidence map›Paper›PMID 31772607›Full record

ArticleCardiovascular therapeutics2019

The Effects of Pitavastatin on Nuclear Factor-Kappa B and ICAM-1 in Human Saphenous Vein Graft Endothelial Culture.

Bulent Demir, Burak Onal, Sibel Ozyazgan, Esra Demir, Vedat Bakuy, Ahmet Gokhan Akkan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Bulent DemirHealth Sciences University, Bakırköy Dr. Sadi Konuk Education And Research Hospital, Department Of Cardiology, Istanbul, Turkey.ORCID 0000-0003-1767-408X
Burak OnalBiruni Univesity Medical Faculty, Department Of Medical Pharmacology, Istanbul, Turkey.
Sibel OzyazganIstabul Cerrahpasa University Medical Faculty, Department Of Medical Pharmacology, Istanbul, Turkey.
Esra DemirHealth Sciences University, Kanuni Sultan Suleyman Education And Research Hospital, Department Of Internal Medicine, Istanbul, Turkey.
Vedat BakuyIstanbul Baskent University Medical Faculty, Department Of Cardiovascular Surgery, Istanbul, Turkey.
Ahmet Gokhan AkkanIstabul Cerrahpasa University Medical Faculty, Department Of Medical Pharmacology, Istanbul, Turkey.
Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi · TRBaşkent University · TRBiruni University · TRSağlık Bilimleri Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study pitavastatin's effects on nuclear factor-kappa B (NF- MATERIALS AND

methodLow-dose (0.1

resultsICAM-1 mRNA expression in the low-dose pitavastatin+TNF-

conclusionPitavastatin increases ICAM-1 mRNA expression in saphenous vein endothelial cells. Furthermore, the effect of pitavastatin on adhesion molecules appears independent of NF-

Indexed as

Cells, CulturedDose-Response Relationship, DrugHumansHuman Umbilical Vein Endothelial CellsHydroxymethylglutaryl-CoA Reductase InhibitorsIntercellular Adhesion Molecule-1NF-kappa BQuinolinesTumor Necrosis Factor-alphaUp-RegulationHydroxymethylglutaryl-CoA Reductase InhibitorsICAM1 protein, humanIntercellular Adhesion Molecule-1NF-kappa BpitavastatinQuinolinesTumor Necrosis Factor-alpha

Identifiers

PMID31772607
PMCPMC6739759
OpenAlexW2943548266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.