ArticleMediators of inflammation2019
A Th2 Cytokine Profile in Appendicular Lavage Fluid Suggests Allergy as a Possible Etiology for Acute Appendicitis.
Article in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The value of interleukin-6 in predicting acute appendicitis in children and distinguishing complicated appendicitis: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- Characterization of Th2 Serum Immune Response in Acute Appendicitis.International journal of molecular sciences · 2026Article
- The Human Appendix and Antibiotics: Choice and Beneficence.ANZ journal of surgery · 2025Article
- A Case of Acute Appendicitis With Mucocele, Serrated Adenoma, and Enterobius vermicularis as Underlying Etiologies.Cureus · 2025Article
- The Exocrine Appendix. Darwin's vestige.ANZ journal of surgery · 2025Article
- Delta neutrophil index, CRP/albumin ratio, procalcitonin, immature granulocytes, and HALP score in acute appendicitis: Best performing biomarker?Open medicine (Warsaw, Poland) · 2025Article
- Compilation of Evidence Supporting the Role of a T Helper 2 Reaction in the Pathogenesis of Acute Appendicitis.International journal of molecular sciences · 2024Review
- Tryptase in Acute Appendicitis: Unveiling Allergic Connections through Compelling Evidence.International journal of molecular sciences · 2024Article
- Flow cytometric characterization of cecal appendix lymphocyte subpopulations in children: a pilot study.Pediatric surgery international · 2023Article
- Eosinophil Granule Proteins Involvement in Acute Appendicitis-An Allergic Disease?International journal of molecular sciences · 2023Article
- Article
- Evaluation of Biomarkers from Peritoneal Fluid as Predictors of Severity for Abdominal Sepsis Patients Following Emergency Laparotomy.Journal of inflammation research · 2023Article
- IL-5 Serum and Appendicular Lavage Fluid Concentrations Correlate with Eosinophilic Infiltration in the Appendicular Wall Supporting a Role for a Hypersensitivity Type I Reaction in Acute Appendicitis.International journal of molecular sciences · 2022Article
- The appendix-mucosal immunity and tolerance in the gut: consequences for the syndromes of appendicitis and its epidemiology.ANZ journal of surgery · 2022Article
- An Evaluation of Serum IgE and Th2-Associated Interleukins in Children With Uncomplicated and Complicated Appendicitis.Frontiers in pediatrics · 2022Article
- Increased IgE Deposition in Appendicular Tissue Specimens Is Compatible with a Type I Hypersensitivity Reaction in Acute Appendicitis.Mediators of inflammation · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute appendicitis is the most frequent surgical abdominal emergency, but its etiology remains poorly understood. Histological examination of the appendix, following its removal due to acute appendicitis, consistently shows features in common with bronchial asthma, suggesting an allergic reaction as a candidate etiologic factor. Here, we propose the concept of appendicular lavage and use it to study the levels of the Th2 cytokines IL-4, IL-5, and IL-9 in patients with a clinical diagnosis of acute appendicitis. The study group included 20 patients with a histological diagnosis of phlegmonous appendicitis, 13 patients with gangrenous appendicitis, and a control group of 8 patients with a clinical diagnosis of appendicitis but with normal histology. Cytokine levels were higher in acute appendicitis. The difference was more pronounced when comparing phlegmonous appendicitis with nonpathological appendicitis (
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