ReviewNature reviews. Neurology2020
The neural and neurocomputational bases of recovery from post-stroke aphasia.
Review in Nature reviews. Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
92 citing papers in PubMed, 4 syntheses or guidelines pooled it, 164 citations in OpenAlex.
- The Role of the Right Language Network and the Multiple-Demand Network in Verbal Semantics: Insights From an Activation Likelihood Estimation Meta-Analysis of 561 Functional Neuroimaging Studies.Human brain mapping · 2025Pooled it
- Comparative Efficacy of Cognitive Training for Post-Stroke Aphasia: A Systematic Review and Network Meta-Analysis.Neurorehabilitation and neural repair · 2024Pooled it
- Repetitive transcranial magnetic stimulation as an alternative therapy for stroke with spasticity: a systematic review and meta-analysis.Journal of neurology · 2021Pooled it
- Neural Resources Supporting Language Production vs. Comprehension in Chronic Post-stroke Aphasia: A Meta-Analysis Using Activation Likelihood Estimates.Frontiers in human neuroscience · 2021Pooled it
- Functional neuroplasticity in chronic post-stroke aphasia following a singing intervention in a cross-over randomised trial.Scientific reports · 2025Trial
- Right C7 neurotomy at the intervertebral foramen plus intensive speech and language therapy versus intensive speech and language therapy alone for chronic post-stroke aphasia: multicentre, randomised controlled trial.BMJ (Clinical research ed.) · 2025Trial
- Efficacy and safety of DL-3-N-butylphthalide in the treatment of ischemic poststroke aphasia: A randomized clinical trial.Annals of clinical and translational neurology · 2024Trial
- Trial
- Trial
- Intermittent Theta Burst Stimulation (iTBS) for Treatment of Chronic Post-Stroke Aphasia: Results of a Pilot Randomized, Double-Blind, Sham-Controlled Trial.Medical science monitor : international medical journal of experimental and clinical research · 2021Trial
- Neuromodulation for restoring and amplifying brain function.Nature neuroscience · 2026Review
- Right Hemisphere Functional Connectivity Increases in Proportion to Left Hemisphere Lesion Size, but Not Within the Language Network.Human brain mapping · 2026Observational
- Right hemisphere involvement in intensive aphasia therapy outcomes: a multimodal neuroimaging concept study.Journal of neurology · 2026Article
- Right hemisphere language network plasticity in aphasia.Brain : a journal of neurology · 2026Article
- Language comprehension in chronic aphasia relies on the language network, not the Multiple Demand network.medRxiv : the preprint server for health sciences · 2026Article
- Circulating IncRNAs and Their Association With Ischemic Stroke Severity and Prognosis: A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- Improving Lexicosemantic Impairments in Post-Stroke Aphasia Using rTMS Targeting the Right Anterior Temporal Lobe.Brain sciences · 2026Article
- Content-function word production in Mandarin-speaking Broca's aphasia: a generative approach.Frontiers in neuroscience · 2026Article
- The nonlinear trajectory of post-stroke aphasia recovery.Frontiers in human neuroscience · 2026Review
- Magnetoencephalography study of the Xingnao Kaiqiao acupuncture during acupuncture and language task states in healthy volunteers: a single-blind, randomized, sham-controlled trial protocol.Frontiers in neurology · 2026Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Language impairment, or aphasia, is a disabling symptom that affects at least one third of individuals after stroke. Some affected individuals will spontaneously recover partial language function. However, despite a growing number of investigations, our understanding of how and why this recovery occurs is very limited. This Review proposes that existing hypotheses about language recovery after stroke can be conceptualized as specific examples of two fundamental principles. The first principle, degeneracy, dictates that different neural networks are able to adapt to perform similar cognitive functions, which would enable the brain to compensate for damage to any individual network. The second principle, variable neuro-displacement, dictates that there is spare capacity within or between neural networks, which, to save energy, is not used under standard levels of performance demand, but can be engaged under certain situations. These two principles are not mutually exclusive and might involve neural networks in both hemispheres. Most existing hypotheses are descriptive and lack a clear mechanistic account or concrete experimental evidence. Therefore, a better neurocomputational, mechanistic understanding of language recovery is required to inform research into new therapeutic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.