Evidence map›Paper›PMID 31772321›Full record

ArticleMucosal immunology2020

Robo4 contributes to the turnover of Peyer's patch B cells.

Ruth Fair-Mäkelä, Milas Ugur, Imtiaz Iftakhar-E-Khuda, Laura Kähäri, Anu Kukkonen-Macchi, Heini-Maria Brenyah, Kati Elima, Masayuki Miyasaka, Oliver Pabst, Sirpa Jalkanen

Open access · bronzeAbstract read
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In one paragraph

Article in Mucosal immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Ruth Fair-MäkeläMediCity Research Laboratory and Institute of Biomedicine, University of Turku, 20520, Turku, Finland.
Milas Ugur *Institute of Molecular Medicine, RWTH Aachen University, 52074, Aachen, Germany.
Imtiaz Iftakhar-E-Khuda *MediCity Research Laboratory and Institute of Biomedicine, University of Turku, 20520, Turku, Finland.
Laura KähäriMediCity Research Laboratory and Institute of Biomedicine, University of Turku, 20520, Turku, Finland.
Anu Kukkonen-MacchiMediCity Research Laboratory and Institute of Biomedicine, University of Turku, 20520, Turku, Finland.
Heini-Maria BrenyahMediCity Research Laboratory and Institute of Biomedicine, University of Turku, 20520, Turku, Finland.
Kati ElimaMediCity Research Laboratory and Institute of Biomedicine, University of Turku, 20520, Turku, Finland.
Masayuki MiyasakaMediCity Research Laboratory and Institute of Biomedicine, University of Turku, 20520, Turku, Finland.
Oliver PabstInstitute of Molecular Medicine, RWTH Aachen University, 52074, Aachen, Germany.
Sirpa JalkanenMediCity Research Laboratory and Institute of Biomedicine, University of Turku, 20520, Turku, Finland. sirpa.jalkanen@utu.fi.
University of Turku · FIRWTH Aachen University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

All leukocytes can get entrance into the draining lymph nodes via the afferent lymphatics but only lymphoid cells can leave the nodes. The molecular mechanisms behind this phenomenon have remained unknown. We employed genome wide microarray analyses of the subcapsular sinus and lymphatic sinus (LS) endothelial cells and found Robo4 to be selectively expressed on LS lymphatics. Further analyses showed high Robo4 expression in lymphatic vessels of Peyer's patches, which only have efferent lymphatic vessels. In functional assays, Robo4-deficient animals showed accumulation of naïve  B cells (CD19

Indexed as

AnimalsAntibodies, BlockingB-LymphocytesHumansLymph NodesMiceMice, Inbred C57BLMice, KnockoutPeyer's PatchesReceptors, Cell SurfaceAntibodies, BlockingReceptors, Cell SurfaceRobo4 protein, mouse

Identifiers

PMID31772321
OpenAlexW2991375598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.