ArticleLeukemia2020
Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL.
Open access · hybridAbstract read
In one paragraph
Article in Leukemia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2.Nature biotechnology · 2026Article
- Low expression of MKRN1 promotes leukemia cell proliferation.European journal of medical research · 2025Article
- A Perspective on Therapeutic Targeting Against Ubiquitin Ligases to Stabilize Tumor Suppressor Proteins.Cancers · 2025Review
- Article
- Multi-omics integration reveals potential stage-specific druggable targets in T-cell acute lymphoblastic leukemia.Genes & diseases · 2024Article
- A critical role of the endothelial S-phase kinase-associated protein 2/phosphatase and tensin homologue axis in angiogenesis and psoriasis.The British journal of dermatology · 2024Article
- SKping cell cycle regulation: role of ubiquitin ligase SKP2 in hematological malignancies.Frontiers in oncology · 2024Review
- MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57Nature communications · 2023Article
- A RUNX1/ETO-SKP2-CDKN1B axis regulates expression of telomerase in t (8;21) acute myeloid leukemia.Cellular and molecular life sciences : CMLS · 2023Article
- Small-molecule compounds inhibiting S-phase kinase-associated protein 2: A review.Frontiers in pharmacology · 2023Review
- Article
- Feasibility study of a novel preparation strategy for anti-CD7 CAR-T cells with a recombinant anti-CD7 blocking antibody.Molecular therapy oncolytics · 2022Article
- Cell adhesion tunes inflammatory TPL2 kinase signal transduction.Cellular and molecular life sciences : CMLS · 2022Article
- E3 ubiquitin ligases in the acute leukemic signaling pathways.Frontiers in physiology · 2022Review
- Tilting MYC toward cancer cell death.Trends in cancer · 2021Review
- Review
- Ubiquitin ligases in cancer: Functions and clinical potentials.Cell chemical biology · 2021Review
- Targeting RFWD2 as an Effective Strategy to Inhibit Cellular Proliferation and Overcome Drug Resistance to Proteasome Inhibitor in Multiple Myeloma.Frontiers in cell and developmental biology · 2021Article
- The Earliest T-Precursors in the Mouse Embryo Are Susceptible to Leukemic Transformation.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 9 institutions in 1 country.
Sonia RodriguezBeckman Research Institute, Gehr Leukemia Center, City of Hope, Duarte, CA, 91010, USA.
Christina AbundisBeckman Research Institute, Gehr Leukemia Center, City of Hope, Duarte, CA, 91010, USA.
Francesco BoccalatteDepartment of Pathology and Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY, 10016, USA.
Purvi MehrotraHerman B Wells Center, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Mark Y ChiangDepartment of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA.
Mary A YuiDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Lin WangHerman B Wells Center, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Huajia ZhangHerman B Wells Center, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Amy ZollmanHerman B Wells Center, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Ricardo Bonfim-SilvaHerman B Wells Center, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Andreas KloetgenDepartment of Pathology and Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY, 10016, USA.
Joycelynne PalmerBeckman Research Institute, Gehr Leukemia Center, City of Hope, Duarte, CA, 91010, USA.
George SanduskyDepartment of Pathology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Mark WunderlichDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Mark H KaplanHerman B Wells Center, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
James C MulloyDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Guido MarcucciBeckman Research Institute, Gehr Leukemia Center, City of Hope, Duarte, CA, 91010, USA.
Iannis AifantisDepartment of Pathology and Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY, 10016, USA.
Angelo A CardosoBeckman Research Institute, Gehr Leukemia Center, City of Hope, Duarte, CA, 91010, USA.
Nadia CarlessoBeckman Research Institute, Gehr Leukemia Center, City of Hope, Duarte, CA, 91010, USA. ncarlesso@coh.org.
Beckman Research InstituteIndiana University Health · USIndiana University – Purdue University Indianapolis · USIndiana University School of MedicineNYU Langone Health · USCincinnati Children's Hospital Medical Center · USCalifornia Institute of Technology · USCity of Hope · USUniversity of Michigan–Ann Arbor · US
Funding
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3MRegulating hematopoietic stem cells and hematopoiesis for clinical efficacyP30DK090948 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E., SROUR, EDWARD F · 2010 to 2014
$3.7MStage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell developmentR01AI136941 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHIANG, MARK Y · 2019 to 2023
$2.5MDirect coregulation of Notch1 by Zmiz1 in T-cell leukemiaR01CA196604 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHIANG, MARK Y · 2015 to 2019
$1.8MPhysiologic Regulation of Hematopoiesis by NotchR01DK097837 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI CARLESSO, NADIA · 2014 to 2017
$1.6MNCI NIH HHS P30 CA033572NCI NIH HHS R01 CA196604NIAID NIH HHS R01 AI136941NIDDK NIH HHS P30 DK090948NIDDK NIH HHS R01 DK097837
Abstract
Timed degradation of the cyclin-dependent kinase inhibitor p27
Indexed as
ApoptosisCell ProliferationGene Expression Regulation, NeoplasticAnimalsFemaleHumansMaleMiceMice, Inbred C57BLMice, Inbred NODMice, KnockoutMice, SCIDPrecursor T-Cell Lymphoblastic Leukemia-LymphomaProtein Kinase InhibitorsS-Phase Kinase-Associated ProteinsTumor Cells, CulturedProtein Kinase InhibitorsS-Phase Kinase-Associated Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.