Evidence map›Paper›PMID 31772290›Full record

Observational studyScientific reports2019

Association between impulsivity traits and body mass index at the observational and genetic epidemiology level.

David Meyre, Sebat Mohamed, Joshua C Gray, Jessica Weafer, James MacKillop, Harriet de Wit

Abstract readObservational Study
In one paragraph

Observational study in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David MeyreDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. meyred@mcmaster.ca.
Sebat MohamedDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Joshua C GrayDepartment of Medical and Clinical Psychology, Uniformed Services University, Bethesda, Maryland, United States of America.ORCID http://orcid.org/0000-0002-5351-561X
Jessica WeaferDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, United States of America.
James MacKillopPeter Boris Centre for Addictions Research, McMaster University/St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada. jmackill@mcmaster.ca.ORCID http://orcid.org/0000-0003-4118-9500
Harriet de WitDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, United States of America.

Funding

The genetic basis of impulsive behavior in humansR01DA032015 · NIDA · UNIVERSITY OF CHICAGO · PI DE WIT, HARRIET · 2011 to 2015
$2.4M
Neurobiological factors underlying sex differences in risk for alcohol abuseK01AA024519 · NIAAA · UNIVERSITY OF KENTUCKY · PI WEAFER, JESSICA J · 2016 to 2020
$598k
NIAAA NIH HHS K01 AA024519NIDA NIH HHS R01 DA032015U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DA032015
6 · The paper itself

Abstract

We investigated the association between impulsivity related traits and BMI at the observational and genetic epidemiology level in a cross-sectional population of healthy young American-European adults. We studied 998 students and university staff of European ancestry recruited from Chicago (Illinois) and Athens (Georgia). We measured 14 impulsivity variables using three broad categories: impulsive choice, action and personality. Weight and height of participants were measured by research assistants. The single-nucleotide polymorphism (SNP) rs3751812 in the fat mass and obesity-associated (FTO) gene was genotyped using the Illumina PsychArray BeadChip platform. Within the three broad domains of impulsivity, 4 parameters (delay discounting of rewards area under the curve and average of k indexes, Conner's continuous performance test, and negative urgency) were associated with BMI. The FTO rs3751812 minor allele T was associated with higher BMI. Of the 14 impulsivity variables, rs3751812 T was associated with more premeditation and perseverance, before and after adjusting for BMI. The association between FTO rs3751812 and BMI adjusted for premeditation remained significant, but disappeared after adjusting for perseverance and for both perseverance and premeditation traits. Our observational and genetic data indicate a complex pattern of association between impulsive behaviors and BMI in healthy young American-European adults.

Indexed as

Body Mass IndexImpulsive BehaviorAdolescentAlpha-Ketoglutarate-Dependent Dioxygenase FTOChoice BehaviorCross-Sectional StudiesEuropeFemaleGenetic Predisposition to DiseaseGenotypeGeorgiaHumansIllinoisMaleMolecular EpidemiologyObesityAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, human

Identifiers

PMID31772290
PMCPMC6879509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.