ArticleScientific reports2019
Fetuin exhibits a strong affinity for plutonium and may facilitate its accumulation in the skeleton.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 18 citations in OpenAlex.
- Review of the anatomical basis for predicting plutonium alpha particle radiation induced osteogenic cancers.Anatomical record (Hoboken, N.J. : 2007) · 2025Review
- Isotopic Fractionation of Natural Uranium in Mice as a Potential Biomarker of Renal Accumulation.Environmental science & technology · 2025Article
- Biogeochemistry of Actinides: Recent Progress and Perspective.ACS environmental Au · 2024Review
- Facile fabrication of hierarchically nanostructured gold electrode for bio-electrochemical applications.Journal of electroanalytical chemistry (Lausanne, Switzerland) · 2022Article
- Use of an Acellular Assay to Study Interactions between Actinides and Biological or Synthetic Ligands.Biomolecules · 2022Article
- Efficient discrimination of transplutonium actinides byChemical science · 2021Article
- Characterizing the general chelating affinity of serum protein fetuin for lanthanides.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
After entering the blood, plutonium accumulates mainly in the liver and the bones. The mechanisms leading to its accumulation in bone are, however, completely unknown. We already know that another uptake pathway not involving the transferrin-mediated pathways is suspected to intervene in the case of the liver. Fetuin, a protein playing an important role in bone metabolism, is proposed as a potential transporter of Pu from serum to bone. For the first time, the binding constants of these two proteins (transferrin and fetuin) with tetravalent plutonium at physiological pH (pH 7.0) were determined by using capillary electrophoresis (CE) coupled with inductively coupled plasma mass spectrometry (ICP-MS). Their very close values (log
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