Evidence map›Paper›PMID 31772225›Full record

ArticleScientific reports2019

Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD

Jeffrey D Roizen, Minoru Asada, Min Tong, Hsin-Hsiung Tai, Louis J Muglia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jeffrey D RoizenDivision of Endocrinology and Diabetes (JDR), and, The Children's Hospital of Philadelphia, Philadelphia, PA, and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States, 19104. roizenj@chop.edu.ORCID http://orcid.org/0000-0002-3384-6200
Minoru AsadaOsaka Shiritsu Sogo Iryo Center, Osaka, Japan.
Min TongDepartment of Pharmaceutical Sciences (MT, HHT), College of Pharmacy, University of Kentucky, Lexington, KY, 40536, USA.
Hsin-Hsiung TaiDepartment of Pharmaceutical Sciences (MT, HHT), College of Pharmacy, University of Kentucky, Lexington, KY, 40536, USA.
Louis J MugliaCenter for Prevention of Preterm Birth (LJM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.ORCID http://orcid.org/0000-0002-0301-8770
University of Kentucky · USChildren's Hospital of Philadelphia · USCincinnati Children's Hospital Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostaglandins (PGs) have critical signaling functions in a variety of processes including the establishment and maintenance of pregnancy, and the initiation of labor. Most PGs are non-enzymatically degraded, however, the two PGs most prominently implicated in the termination of pregnancy, including the initiation of labor, prostaglandin E2 (PGE

Indexed as

Abortion, SpontaneousAnimalsCyclooxygenase 1Cyclooxygenase 2DinoprostDinoprostoneEmbryo ImplantationFemaleFetusGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicGenotypeGestational AgeHydroxyprostaglandin DehydrogenasesIndomethacinMaternal Death15-hydroxyprostaglandin dehydrogenaseCyclooxygenase 1Cyclooxygenase 2DinoprostDinoprostoneHydroxyprostaglandin DehydrogenasesIndomethacinMembrane ProteinsProgesteronePtgs1 protein, mousePtgs2 protein, mouseRNA, Messenger

Identifiers

PMID31772225
PMCPMC6879597
OpenAlexW2991082415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.