Evidence map›Paper›PMID 31772104›Full record

Observational studyBMJ open2019

Cohort profile: the Neonatal Intensive Care Unit Hospital Exposures and Long-Term Health (NICU-HEALTH) cohort, a prospective preterm birth cohort in New York City.

Annemarie Stroustrup, Jennifer B Bragg, Emily A Spear, Andrea Aguiar, Emily Zimmerman, Joseph R Isler, Stefanie A Busgang, Paul C Curtin, Chris Gennings, Syam S Andra and 1 more

3 registry-linked trialsOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01420029 completednot on this map

Hospital-Based Phthalate Exposure in Very Low Birth Weight Neonates

TypeobservationalSponsorIcahn School of Medicine at Mount SinaiRan2011 to 2013Enrolled81ConditionsLow Birth Weight Neonates
NCT01963065 completednot on this map

Chemical Exposures and Infant Outcomes in the Neonatal Intensive Care Unit

TypeobservationalSponsorIcahn School of Medicine at Mount SinaiRan2015 to 2020Enrolled239ConditionsPreterm Birth
NCT03061890 completednot on this map

Developmental Impact of Neonatal Intensive Care Unit (NICU) Exposures: Environmental Influences on Child Health Outcomes (ECHO)

Typeobservational_patient_registrySponsorAlbert Einstein College of MedicineRan2017 to 2023Enrolled600ConditionsPrematurity
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Annemarie StroustrupPediatrics, Icahn School of Medicine at Mount Sinai, New York City, New York, USA annemarie.stroustrup@mssm.edu.ORCID 0000-0002-5667-6195
Jennifer B BraggPediatrics, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Emily A SpearPediatrics, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Andrea AguiarBeckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Emily ZimmermanCommunication Sciences and Disorders, Northeastern University, Boston, Massachusetts, USA.
Joseph R IslerPediatrics, Columbia University, New York City, New York, USA.
Stefanie A BusgangEnvironmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Paul C CurtinEnvironmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Chris GenningsEnvironmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Syam S AndraEnvironmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Manish AroraEnvironmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Icahn School of Medicine at Mount Sinai · USPediatrics and Genetics · USNortheastern University · USUniversity of Illinois Urbana-Champaign · US

Funding

The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2014 to 2026
$21.3M
The Illinois Kids Development Study ECHO Pregnancy and Pediatric CohortUH3OD023272 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Andrea Aguiar, Susan L Schantz · 2018 to 2026
$18.6M
Developmental Impact of NICU Exposures (DINE)UH3OD023320 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ASCHNER, JUDY LYNN, STROUSTRUP, ANNEMARIE · 2018 to 2022
$14.5M
Developmental Impact of NICU Exposures (DINE)UG3OD023320 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ASCHNER, JUDY LYNN, TEITELBAUM, SUSAN L · 2016 to 2017
$6.1M
Chemical Exposures and Infant Outcomes in the Neonatal Intensive Care UnitK23ES022268 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STROUSTRUP, ANNEMARIE · 2013 to 2017
$731k
NIEHS NIH HHS K23 ES022268NIEHS NIH HHS P30 ES023515NIH HHS UG3 OD023320NIH HHS UH3 OD023272NIH HHS UH3 OD023320
6 · The paper itself

Abstract

purposeThe Neonatal Intensive Care Unit Hospital Exposures and Long-Term Health (NICU-HEALTH) longitudinal preterm birth cohort studies the impact of the NICU exposome on early-life development. NICU-HEALTH collects multiple biospecimens, complex observational and survey data and comprehensive multisystem outcome assessments to allow measurement of the impact of modifiable environmental exposures during the preterm period on neurodevelopmental, pulmonary and growth outcomes.

participantsModerately preterm infants without genetic or congenital anomalies and their mothers are recruited from an urban academic medical centre level IV NICU in New York City, New York, USA. Recruitment began in 2011 and continues through multiple enrolment phases to the present with goal enrolment of 400 infants. Follow-up includes daily data collection throughout the NICU stay and six follow-up visits in the first 2 years. Study retention is 77% to date, with the oldest patients turning age 8 in 2019. FINDINGS TO DATE: NICU-HEALTH has already contributed significantly to our understanding of phthalate exposure in the NICU. Phase I produced the first evidence of the clinical impact of phthalate exposure in the NICU population. Further study identified specific sources of exposure to clinically relevant phthalate mixtures in the NICU. FUTURE PLANS: Follow-up from age 3 to 12 is co-ordinated through integration with the Environmental Influences on Child Health Outcomes (ECHO) programme. The NICU-HEALTH cohort will generate a wealth of biomarker, clinical and outcome data from which future studies of the impact of early-life chemical and non-chemical environmental exposures can benefit. Findings from study of this cohort and other collaborating environmental health cohorts will likely translate into improvements in the hospital environment for infant development. TRIAL REGISTRATION NUMBERS: This observational cohort is registered with ClinicalTrials.gov (NCT01420029 and NCT01963065).

Indexed as

Infant, PrematureInfant, Very Low Birth WeightIntensive Care Units, NeonatalChild DevelopmentDevelopmental DisabilitiesEnvironmental ExposureFemaleHumansInfantInfant, NewbornMaleNew York CityPhthalic AcidsProspective StudiesResearch Designphthalic acidPhthalic Acidschildren’s environmental healthlongitudinal birth cohortneonatal intensive care unitNICUprematurity

Identifiers

PMID31772104
PMCPMC6887035
OpenAlexW2990973418

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.