Evidence map›Paper›PMID 31772059›Full record

ArticlemBio2019

The Toxin-Antitoxin MazEF Drives Staphylococcus aureus Biofilm Formation, Antibiotic Tolerance, and Chronic Infection.

Dongzhu Ma, Jonathan B Mandell, Niles P Donegan, Ambrose L Cheung, Wanyan Ma, Scott Rothenberger, Robert M Q Shanks, Anthony R Richardson, Kenneth L Urish

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 110 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Insights into toxin-antitoxin systems in the genusApplied and environmental microbiology · 2025
    Review
  7. Article
  8. Development of a Potent and FunctionalJournal of medicinal chemistry · 2025
    Article
  9. Article
  10. In Vitro Analysis of Interactions BetweenAntibiotics (Basel, Switzerland) · 2025
    Article
  11. Article
  12. The Secondary Resistome of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2025
    Article
  13. Type II Toxin-Antitoxin Systems inInfection and drug resistance · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dongzhu MaArthritis and Arthroplasty Design Group, Department of Orthopaedic Surgery, College of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jonathan B MandellArthritis and Arthroplasty Design Group, Department of Orthopaedic Surgery, College of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Niles P DoneganDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Ambrose L CheungDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Wanyan MaArthritis and Arthroplasty Design Group, Department of Orthopaedic Surgery, College of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Scott RothenbergerClinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Robert M Q ShanksDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-7699-5396
Anthony R RichardsonDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kenneth L UrishArthritis and Arthroplasty Design Group, Department of Orthopaedic Surgery, College of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA urishk2@upmc.edu.ORCID 0000-0002-4511-1308
University of Pittsburgh · USDartmouth College · US

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Marlene Behrmann · 1989 to 2026
$17.8M
Institutional Career Development CoreKL2TR001856 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, KRISTIN N, RUBIO, DORIS M · 2016 to 2025
$13.8M
Biofilm antibiotic tolerance in periprosthetic joint infectionK08AR071494 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI URISH, KENNETH L · 2017 to 2021
$831k
NCATS NIH HHS KL2 TR001856NEI NIH HHS P30 EY008098NIAMS NIH HHS K08 AR071494
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BiofilmsDrug Resistance, BacterialAnimalsAnti-Bacterial AgentsAntitoxinsBacterial ProteinsBacterial ToxinsChronic DiseaseFemaleHumansMaleMiceMice, Inbred C57BLStaphylococcal InfectionsStaphylococcus aureusToxin-Antitoxin SystemsAnti-Bacterial AgentsAntitoxinsBacterial ProteinsBacterial ToxinsbiofilmicaADBCMazFperiprosthetic joint infectionStaphylococcus aureussurgical infectiontoxin-antitoxin (TA) systems

Identifiers

PMID31772059
PMCPMC6879715
OpenAlexW2990820597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.