ArticleProceedings of the National Academy of Sciences of the United States of America2019
The association between serotonin transporter availability and the neural correlates of fear bradycardia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Nocturnal Risk Assessment and Its Association With Anxiety Symptoms.Psychophysiology · 2026Trial
- Stretch-Induced Muscle Responses Under Threat Versus Safety.The European journal of neuroscience · 2026Article
- Genetic Inactivation of the Serotonin Transporter Dysregulates Expression of Neurotransmission Genes and Genome-Wide DNA Methylation Levels in the Medial Prefrontal Cortex of Male Rats During Postnatal Development.Developmental neurobiology · 2025Article
- Serotonin transporter knockout in rats reduces beta- and gamma-band functional connectivity between the orbitofrontal cortex and amygdala during auditory discrimination.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat.Communications biology · 2024Article
- Genetic differences associated with dopamine and serotonin release mediate fear-induced bradycardia in the human brain.Translational psychiatry · 2024Review
- Neural patterns of threat response in adolescents predict vulnerability for and resilience against internalizing symptoms during COVID-19 waves.Neuroimage. Reports · 2023Article
- The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies.Brain sciences · 2023Review
- Beyond Fear, Extinction, and Freezing: Strategies for Improving the Translational Value of Animal Conditioning Research.Current topics in behavioral neurosciences · 2023Article
- Characterizing cardiac autonomic dynamics of fear learning in humans.Psychophysiology · 2022Article
- Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons.Development (Cambridge, England) · 2022Article
- Stimulation of the ventromedial prefrontal cortex blocks the return of subcortically mediated fear responses.Translational psychiatry · 2022Article
- Freezing revisited: coordinated autonomic and central optimization of threat coping.Nature reviews. Neuroscience · 2022Review
- Novel Antidepressant-Like Properties of the Iron Chelator Deferiprone in a Mouse Model of Depression.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Article
- The gene environment aetiology of freezing and its relationship with internalizing symptoms during adolescence.EBioMedicine · 2022Article
- Postural freezing relates to startle potentiation in a human fear-conditioning paradigm.Psychophysiology · 2022Article
- Genetic influences on central and peripheral nervous system activity during fear conditioning.Translational psychiatry · 2022Article
- Alterations of mitochondrial dynamics in serotonin transporter knockout rats: A possible role in the fear extinction recall mechanisms.Frontiers in behavioral neuroscience · 2022Article
- Fear Extinction and Predictive Trait-Like Inter-Individual Differences in Rats Lacking the Serotonin Transporter.International journal of molecular sciences · 2021Article
- Defensive freezing and its relation to approach-avoidance decision-making under threat.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Susceptibility to stress-related psychopathology is associated with reduced expression of the serotonin transporter (5-HTT), particularly in combination with stress exposure. Aberrant physiological and neuronal responses to threat may underlie this increased vulnerability. Here, implementing a cross-species approach, we investigated the association between 5-HTT expression and the neural correlates of fear bradycardia, a defensive response linked to vigilance and action preparation. We tested this during threat anticipation induced by a well-established fear conditioning paradigm applied in both humans and rodents. In humans, we studied the effect of the common 5-HTT-linked polymorphic region (5-HTTLPR) on bradycardia and neural responses to anticipatory threat during functional magnetic resonance imaging scanning in healthy volunteers (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.