ArticleProceedings of the National Academy of Sciences of the United States of America2019
Mechanical stress compromises multicomponent efflux complexes in bacteria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Nano-kinetic implant surface mediates osteo-antibacterial synergy through electromagnetic-mechanical coupling.Nature communications · 2026Article
- Article
- Exploring bacteria-surface interactions with a fluorescent membrane tension probe.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- E. coli filament buckling modulates Min patterning and cell division.Nature communications · 2025Article
- Physical communication pathways in bacteria: an extra layer to quorum sensing.Biophysical reviews · 2025Review
- Bacterial Adhesion on Soft Surfaces: The Dual Role of Substrate Stiffness and Bacterial Growth Stage.Microorganisms · 2025Article
- Transporter excess and clustering facilitate adaptor protein shuttling for bacterial efflux.Cell reports. Physical science · 2025Article
- Intermittent proton bursts of single lactic acid bacteria.Chemical science · 2024Article
- Key Stress Response Mechanisms of Probiotics During Their Journey Through the Digestive System: A Review.Probiotics and antimicrobial proteins · 2023Review
- Mechanical stimuli activate gene expression via a cell envelope stress sensing pathway.Scientific reports · 2023Article
- Mechanobiology as a tool for addressing the genotype-to-phenotype problem in microbiology.Biophysics reviews · 2023Review
- Quiescence ofMicroorganisms · 2023Article
- Microfluidic techniques for mechanical measurements of biological samples.Biophysics reviews · 2023Review
- The Discovery of the Role of Outer Membrane Vesicles against Bacteria.Biomedicines · 2022Review
- Mechanical Stabilization of a Bacterial Adhesion Complex.Journal of the American Chemical Society · 2022Article
- Engineered Living Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Effects of Nanopillar Size and Spacing on Mechanical Perturbation and Bactericidal Killing Efficiency.Nanomaterials (Basel, Switzerland) · 2021Article
- Cell biomechanics and mechanobiology in bacteria: Challenges and opportunities.APL bioengineering · 2020Review
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
Physical forces have a profound effect on growth, morphology, locomotion, and survival of organisms. At the level of individual cells, the role of mechanical forces is well recognized in eukaryotic physiology, but much less is known about prokaryotic organisms. Recent findings suggest an effect of physical forces on bacterial shape, cell division, motility, virulence, and biofilm initiation, but it remains unclear how mechanical forces applied to a bacterium are translated at the molecular level. In Gram-negative bacteria, multicomponent protein complexes can form rigid links across the cell envelope and are therefore subject to physical forces experienced by the cell. Here we manipulate tensile and shear mechanical stress in the bacterial cell envelope and use single-molecule tracking to show that octahedral shear (but not hydrostatic) stress within the cell envelope promotes disassembly of the tripartite efflux complex CusCBA, a system used by
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.