Evidence map›Paper›PMID 31772017›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals.

Nicholas R Casewell, Daniel Petras, Daren C Card, Vivek Suranse, Alexis M Mychajliw, David Richards, Ivan Koludarov, Laura-Oana Albulescu, Julien Slagboom, Benjamin-Florian Hempel and 23 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 70 citations in OpenAlex.

  1. The genetic foundations of convergent traits.Nature reviews. Genetics · 2026
    Review
  2. Genome of venomous caterpillarProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  6. Hyperpolarization Modulation of the T-Type hCaAngewandte Chemie (International ed. in English) · 2025
    Article
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  9. Review
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  14. Convergent evolution of toxin resistance in animals.Biological reviews of the Cambridge Philosophical Society · 2022
    Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 19 institutions in 10 countries.

Nicholas R CasewellCentre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, United Kingdom; nicholas.casewell@lstmed.ac.uk.ORCID 0000-0002-8035-4719
Daniel PetrasInstitut für Chemie, Technische Universität Berlin, 10623 Berlin, Germany.ORCID 0000-0002-6561-3022
Daren C CardDepartment of Biology, University of Texas at Arlington, Arlington, TX 76010.
Vivek SuranseEvolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, 560012 Bangalore, India.
Alexis M MychajliwDepartment of Biology, Stanford University, Stanford, CA 94305.
David RichardsSchool of Life Sciences, University of Nottingham, University Park, NG7 2RD Nottingham, United Kingdom.
Ivan KoludarovEcology and Evolution Unit, Okinawa Institute of Science and Technology, Onna, Kunigami-gun, Okinawa, 904-0495, Japan.
Laura-Oana AlbulescuCentre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, United Kingdom.
Julien SlagboomDivision of BioAnalytical Chemistry, Amsterdam Institute of Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, 1081 LA Amsterdam, The Netherlands.
Benjamin-Florian HempelInstitut für Chemie, Technische Universität Berlin, 10623 Berlin, Germany.
Neville M NgumSchool of Life Sciences, University of Nottingham, University Park, NG7 2RD Nottingham, United Kingdom.
Rosalind J KennerleyDurrell Wildlife Conservation Trust, Les Augrès Manor, Trinity, Jersey JE3 5BP, British Channel Islands, United Kingdom.
Jorge L BroccaSOH Conservación, Apto. 401 Residencial Las Galerías, Santo Domingo, 10130, Dominican Republic.
Gareth WhiteleyCentre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, United Kingdom.
Robert A HarrisonCentre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, United Kingdom.
Fiona M S BoltonCentre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, United Kingdom.
Jordan DebonoVenom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia, QLD 4067, Australia.
Freek J VonkNaturalis Biodiversity Center, 2333 CR Leiden, The Netherlands.
Jessica AlföldiVertebrate Genomics, Broad Institute of MIT and Harvard, Cambridge, MA 02142.
Jeremy JohnsonVertebrate Genomics, Broad Institute of MIT and Harvard, Cambridge, MA 02142.
Elinor K KarlssonVertebrate Genomics, Broad Institute of MIT and Harvard, Cambridge, MA 02142.ORCID 0000-0002-4343-3776
Kerstin Lindblad-TohVertebrate Genomics, Broad Institute of MIT and Harvard, Cambridge, MA 02142.
Ian R MellorSchool of Life Sciences, University of Nottingham, University Park, NG7 2RD Nottingham, United Kingdom.
Roderich D SüssmuthInstitut für Chemie, Technische Universität Berlin, 10623 Berlin, Germany.
Bryan G FryVenom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia, QLD 4067, Australia.ORCID 0000-0001-6661-1283
Sanjaya KuruppuMonash Venom Group, Department of Pharmacology, Biomedicine Discovery Institute, Monash University, VIC 3800, Australia.
Wayne C HodgsonMonash Venom Group, Department of Pharmacology, Biomedicine Discovery Institute, Monash University, VIC 3800, Australia.
Jeroen KoolDivision of BioAnalytical Chemistry, Amsterdam Institute of Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, 1081 LA Amsterdam, The Netherlands.
Todd A CastoeDepartment of Biology, University of Texas at Arlington, Arlington, TX 76010.
Ian BarnesDepartment of Earth Sciences, Natural History Museum, SW7 5BD London, United Kingdom.ORCID 0000-0001-8322-6918
Kartik SunagarEvolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, 560012 Bangalore, India.ORCID 0000-0003-0998-1581
Eivind A B UndheimCentre for Advanced Imaging, The University of Queensland, Brisbane QLD 4072, Australia.ORCID 0000-0002-8667-3999
Samuel T TurveyInstitute of Zoology, Zoological Society of London, Regent's Park, NW1 4RY London, United Kingdom.
Liverpool School of Tropical Medicine · GBBroad Institute · USThe University of Queensland · AUIndian Institute of Science Bangalore · INTechnische Universität Berlin · DEUniversity of Nottingham · GBVrije Universiteit Amsterdam · NLAustralian Regenerative Medicine Institute · AUDurrell Wildlife Conservation Trust · JEHarvard University · USHokkaido University · JPMonash University · AUNatural History Museum · GBNaturalis Biodiversity Center · NLOkinawa Institute of Science and Technology Graduate University · JPThe University of Texas at Arlington · USUniversity of California San Diego · USUniversity of East Anglia · GBZoological Society of London · GB

Funding

The 200 mammals project: sequencing genomes by a novel cost-effective method, yielding a high resolution annotation of the human genome.R01HG008742 · NHGRI · BROAD INSTITUTE, INC. · PI BIRREN, BRUCE W., KARLSSON, ELINOR · 2016 to 2020
$2.8M
NHGRI NIH HHS R01 HG008742Wellcome TrustWellcome Trust 200517/Z/16/Z
6 · The paper itself

Abstract

Venom systems are key adaptations that have evolved throughout the tree of life and typically facilitate predation or defense. Despite venoms being model systems for studying a variety of evolutionary and physiological processes, many taxonomic groups remain understudied, including venomous mammals. Within the order Eulipotyphla, multiple shrew species and solenodons have oral venom systems. Despite morphological variation of their delivery systems, it remains unclear whether venom represents the ancestral state in this group or is the result of multiple independent origins. We investigated the origin and evolution of venom in eulipotyphlans by characterizing the venom system of the endangered Hispaniolan solenodon (

Indexed as

EutheriaEvolution, MolecularShrewsAnimalsGene DuplicationGenomeMalePhylogenyProteomicsTissue KallikreinsVenomsTissue KallikreinsVenomsconvergent molecular evolutiongene duplicationgenotype phenotypekallikrein toxinvenom systems

Identifiers

PMID31772017
PMCPMC6926037
OpenAlexW2990231438

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.